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GSK-J4 Hydrochloride

GSK-J4 Hydrochloride Structure
GSK-J4 Hydrochloride structure
CAS No.
1797983-09-5
Chemical Name:
GSK-J4 Hydrochloride
Synonyms
1797983-09-5 (HCl);GSK-J4 Hydrochloride;TYXWLTBYINKVNT-UHFFFAOYSA-N;Ethyl N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alaninate hydrochloride;Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate hydrochloride;Histone Demethylase,diabetic,Th17,mice,cells,inflammation,Th1,H3K27me3/me2,dendritic,GSKJ4 Hydrochloride,TGF-β,inhibit,Inhibitor,GSK J4 Hydrochloride,demethylase,GSK-J4,GSK-J-4 Hydrochloride
CBNumber:
CB12700565
Molecular Formula:
C24H28ClN5O2
Molecular Weight:
453.96442
MDL Number:
MFCD26142638
MOL File:
1797983-09-5.mol
Last updated:2023-05-18 11:31:10
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GSK-J4 Hydrochloride Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO:60.83(Max Conc. mg/mL);134.0(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:7):0.1(Max Conc. mg/mL);0.22(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);66.08(Max Conc. mM)
Ethanol:55.0(Max Conc. mg/mL);121.15(Max Conc. mM)
Water:10.0(Max Conc. mg/mL);22.03(Max Conc. mM)
form A crystalline solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314-H290
Precautionary statements  P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405

GSK-J4 Hydrochloride price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 12073 GSK-J4 (hydrochloride) ≥95% 1797983-09-5 5mg $57 2024-03-01 Buy
Cayman Chemical 12073 GSK-J4(hydrochloride) ≥98% 1797983-09-5 25mg $179 2024-03-01 Buy
Cayman Chemical 12073 GSK-J4 (hydrochloride) ≥95% 1797983-09-5 1mg $25 2021-12-16 Buy
Cayman Chemical 12073 GSK-J4 (hydrochloride) ≥95% 1797983-09-5 10mg $107 2024-03-01 Buy
Cayman Chemical 12073 GSK-J4 (hydrochloride) ≥95% 1797983-09-5 50mg $302 2024-03-01 Buy
Product number Packaging Price Buy
12073 5mg $57 Buy
12073 25mg $179 Buy
12073 1mg $25 Buy
12073 10mg $107 Buy
12073 50mg $302 Buy

GSK-J4 Hydrochloride Chemical Properties,Uses,Production

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 (hydrochloride) is an ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 with an IC50 value greater than 50 μM in vitro. Acting as a prodrug, GSK-J4 is rapidly hydrolyzed in cells to the otherwise cell impermeable GSK-J1, which exhibits an IC50 value of 60 nM for the purified enzyme. When administered to human primary macrophages, GSK-J4 can reduce LPS-induced proinflammatory cytokine production, most notably including that of TNFα (IC50 = 9 μM).

Uses

GSK-J4 Hydrochloride is a histone demethylase JMJD3/UTX inhibitors which blocks demethylation of histone H3K27.

GSK-J4 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-J4 Hydrochloride Suppliers

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9340 55
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED
60
Hangzhou FandaChem Co.,Ltd. 		55
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
BOC Sciences 65
GSK-J4 Hydrochloride TYXWLTBYINKVNT-UHFFFAOYSA-N Ethyl N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alaninate hydrochloride 1797983-09-5 (HCl) Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate hydrochloride Histone Demethylase,diabetic,Th17,mice,cells,inflammation,Th1,H3K27me3/me2,dendritic,GSKJ4 Hydrochloride,TGF-β,inhibit,Inhibitor,GSK J4 Hydrochloride,demethylase,GSK-J4,GSK-J-4 Hydrochloride 1797983-09-5 797983-09-5