D8-MMAE
- CAS No.
- 2070009-72-0
- Chemical Name:
- D8-MMAE
- Synonyms
- MMAE-d8;D8-MMAE;2H8]-MMAE;MMAE-d-8,MMAE d8,MMAEd8;D8-Monomethyl auristatin E
- CBNumber:
- CB12715624
- Molecular Formula:
- C39H59D8N5O7
- Molecular Weight:
- 726.027874224
- MDL Number:
- MFCD28386277
- MOL File:
- 2070009-72-0.mol
D8-MMAE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3368 | D8-MMAE 99.29% | 2070009-72-0 | 1mg | $1320 | 2021-12-16 | Buy |
| ChemScene | CS-3368 | D8-MMAE 99.29% | 2070009-72-0 | 5mg | $3000 | 2021-12-16 | Buy |
| ChemScene | CS-3368 | D8-MMAE 99.29% | 2070009-72-0 | 10mg | $5640 | 2021-12-16 | Buy |
| aablocks | AA01EOLQ | D8-MMAE 99% | 2070009-72-0 | 10mg | $6302 | 2021-12-16 | Buy |
| aablocks | AA01EOLQ | D8-MMAE 99% | 2070009-72-0 | 5mg | $3369 | 2021-12-16 | Buy |
D8-MMAE Chemical Properties,Uses,Production
Biological Activity
D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE. MMAE is a tubulin inhibitor that inhibits mitosis.
in vivo
Intratumoral MMAE concentrations consistently correlates with the extent of tumor growth inhibition in tumor xenograft models. IHC analysis reveals that nonbinding control-treated tumors consist of both CD30 + and CD30 - cells, presumably because they do not kill either CD30 + or CD30 - Karpas 299 cells. Only CD30 - cells are found in cAC10-vcMMAF-treated tumors, illustrating that cAC10-vcMMAF eliminates most CD30 + cells. Interestingly, the two tumors that relapses from cAC10-vcMMAE treatment are also found to be CD30 - by the end of study, indicating a small fraction of CD30 - cells might have escaped from bystander killing in these two remaining tumors.
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target
| Auristatin
|
D8-MMAE Preparation Products And Raw materials
Raw materials
Preparation Products
D8-MMAE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| ChemExpress | +86-021-58950125 | info@chemexpress.com | China | 566 | 58 |
| Levena (Suzhou) Biopharma Co., Ltd. | 0512-81877925 051281877925 | info@levena.cn | China | 48 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 646 | 55 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 2804 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
