ChemicalBook >> CAS DataBase List >>2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- structure

CAS No.: 1374356-45-2

Chemical Name:: 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Synonyms: (s)-g-fitinib;(S)-CRIZOTINIB;ent-crizotinib;Crizotinib, (S)-;Crizotinib S-Isomer;Crizotinib impurity A;Crizotinib Impurity 24;CRIZOTINIB, S-ENANTIOMER;CRIZOTINIB CHIRAL IMPURITY;3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

CBNumber:: CB12729650

Molecular Formula:: C21H22Cl2FN5O

Molecular Weight:: 450.34

MDL Number:: MFCD22126092

MOL File:: 1374356-45-2.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

Request For Quotation

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Properties

Boiling point	599.2±50.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml
form	A solid
pka	9.81±0.10(Predicted)
CAS DataBase Reference	1374356-45-2

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	6025	(S)-Crizotinib ≥98%(HPLC)	1374356-45-2	10	$137	2021-12-16	Buy
Tocris	6025	(S)-Crizotinib ≥98%(HPLC)	1374356-45-2	50	$578	2021-12-16	Buy
TRC	C785005	(S)-Crizotinib	1374356-45-2	5mg	$275	2021-12-16	Buy
TRC	C785005	(S)-Crizotinib	1374356-45-2	2.5mg	$180	2021-12-16	Buy
TRC	C785005	(S)-Crizotinib	1374356-45-2	1mg	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
6025	10	$137	Buy
6025	50	$578	Buy
C785005	5mg	$275	Buy
C785005	2.5mg	$180	Buy
C785005	1mg	$80	Buy

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Chemical Properties,Uses,Production

Characteristics

MTH1 (NUDT1)-selective inhibitor.

Uses

(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.

Definition

ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib.

Biological Activity

(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

target

Target	Value
MTH1 (Cell-free assay)	72 nM

storage

Store at RT

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9338	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Adamas Reagent, Ltd.	400-6009262 16621234537	zhangsn@titansci.com	China	14113	59

Supplier	Advantage
career henan chemical co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Adamas Reagent, Ltd.	59

View Lastest Price from 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-02	2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 1374356-45-2	US $1.00 / g	1g	99%	200g	Career Henan Chemical Co

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
1374356-45-2
US $1.00 / g
99%
Career Henan Chemical Co

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Spectrum

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-(1374356-45-2)¹HNMR

1374356-45-2(2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-)Related Search:

Lead Selenium Diethyl sulfate LEUHISTIN Angeli’s Salt

Lignosulfonic acid Everolimus KU-55933 (ATM Kinase Inhibitor) Sunitinib Malate Crizotinib

TH588 AZD-9291

1of3

(S)-CRIZOTINIB 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Crizotinib impurity A CRIZOTINIB CHIRAL IMPURITY (s)-g-fitinib Crizotinib S-Isomer Crizotinib Impurity 24 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine Crizotinib, (S)- ent-crizotinib mutT,inhibit,nucleotide,Apoptosis,(S) crizotinib,homologue,Inhibitor,activity,anticancer,pool,(S)-Crizotinib,(S)crizotinib,DNA/RNA Synthesis CRIZOTINIB, S-ENANTIOMER 1374356-45-2 Inhibitors