Dmt-2'fluoro-da(bz) amidite
- CAS No.
- 136834-22-5
- Chemical Name:
- Dmt-2'fluoro-da(bz) amidite
- Synonyms
- 2'-Fluoro-dA CEP;2’-F-dA(Bz) Amidite;2'-F-Bz-A Phosphoramidite;Bz-2'-F-dA Phosphoramidite;Dmt-2'fluoro-da(bz) amidite;Dmt-2'fluoro-da(bz) amidite;2'-F-Bz-dA Phosphoramidite;2'-F-N6-Bz-dA phosphoramidite;2'-F-Bz-dA-CE-Phosphoramidite;2'-F-dA(Bz)-CE Phosphoramidite
- CBNumber:
- CB13141318
- Molecular Formula:
- C47H51FN7O7P
- Molecular Weight:
- 875.92
- MDL Number:
- MFCD12912392
- MOL File:
- 136834-22-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
Dmt-2'fluoro-da(bz) amidite price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J64064 | N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-(2-cyanoethyl diisopropylphosphoramidite), 98% | 136834-22-5 | 1g | $123.65 | 2024-03-01 | Buy |
TRC | B208313 | (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)Diisopropylphosphoramidite | 136834-22-5 | 1g | $240 | 2021-12-16 | Buy |
AK Scientific | 2404CT | Dmt-2'fluoro-da(bz)amidite | 136834-22-5 | 500mg | $151 | 2021-12-16 | Buy |
AK Scientific | 2404CT | Dmt-2'fluoro-da(bz)amidite | 136834-22-5 | 1g | $218 | 2021-12-16 | Buy |
Biosynth Carbosynth | PB08393 | N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite | 136834-22-5 | 2g | $220 | 2021-12-16 | Buy |
Dmt-2'fluoro-da(bz) amidite Chemical Properties,Uses,Production
Chemical Properties
White to Light yellow powder to crystal.
Uses
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (Dmt-2'fluoro-da(bz) amidite) is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA inhibitors.
Synthesis
3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.
Dmt-2'fluoro-da(bz) amidite Preparation Products And Raw materials
Raw materials
Preparation Products
Dmt-2'fluoro-da(bz) amidite Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1642 | 58 |
Hefei Huana Biomedical Technology Co.,Ltd. | +86-15900695956 | shiqin.he@huanaok.com.cn | China | 96 | 58 |
Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15954 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
NINGBOBENKANGJS PHARMTECHCO., LTD | +8615990591583 15990591583 | CHINA | 2029 | 58 | |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9626 | 58 |
View Lastest Price from Dmt-2'fluoro-da(bz) amidite manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-03-22 | 2'-F-dA(Bz) CE Phosphoramidite
136834-22-5
|
US $100.00 / kg | 0.009999999776482582kg | 99% | 5tons | SHANGHAI NOVRIBO BIOTECH | ||
2023-03-14 | N6-Bz-5'-O-DMT-2'-fluoro-dA-CE
136834-22-5
|
US $0.00 / mg | 100mg | ≥99% | 20tons | Hefei Huana Biomedical Technology Co.,Ltd. | ||
2022-09-27 | N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
136834-22-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
- 2'-F-dA(Bz) CE Phosphoramidite
136834-22-5
- US $100.00 / kg
- 99%
- SHANGHAI NOVRIBO BIOTECH
- N6-Bz-5'-O-DMT-2'-fluoro-dA-CE
136834-22-5
- US $0.00 / mg
- ≥99%
- Hefei Huana Biomedical Technology Co.,Ltd.
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
136834-22-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.