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Boc-N-Me-Val-OH

Boc-N-Me-Val-OH structure

CAS No.: 45170-31-8

Chemical Name:: Boc-N-Me-Val-OH

Synonyms: Boc-N-me-Val;BOC-N-ME-VAL-OH;Boc-L-N-Me-Val-OH;BOC-MEVAL-OH;BOC-L-MEVAL-OH;BOC-N-ME-VALINE;)amino)-3-methyL;Boc-N-Me-L-Val-OH;N-Boc-N-methylvaline;BOC-N-METHYL-L-VAL-OH

CBNumber:: CB1401257

Molecular Formula:: C11H21NO4

Molecular Weight:: 231.29

MDL Number:: MFCD00038760

MOL File:: 45170-31-8.mol

MSDS File:: SDS

Last updated:2024-04-12 23:00:59

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Boc-N-Me-Val-OH Properties

Melting point	45-60°C
Boiling point	322.4±21.0 °C(Predicted)
alpha	-94 º (c=0.5% in ethanol)
Density	1.069±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	4.03±0.10(Predicted)
form	Solid
color	Off-White
optical activity	[α]20/D 94±3°, c = 0.5% in ethanol
BRN	2646180
InChI	InChI=1S/C11H21NO4/c1-7(2)8(9(13)14)12(6)10(15)16-11(3,4)5/h7-8H,1-6H3,(H,13,14)/t8-/m0/s1
InChIKey	XPUAXAVJMJDPDH-QMMMGPOBSA-N
SMILES	C(O)(=O)[C@H](C(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference	45170-31-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

HazardClass

IRRITANT

HS Code

29225090

NFPA 704

	1
0		0

Boc-N-Me-Val-OH price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53085	Boc-N-Me-Val-OH Novabiochem?	45170-31-8	5G	$135	2024-03-01	Buy
Sigma-Aldrich	15538	Boc-N-Me-Val-OH ≥99.0% (TLC)	45170-31-8	1g	$39.44	2024-03-01	Buy
Alfa Aesar	H62771	N-Boc-N-methyl-L-valine, 95%	45170-31-8	1g	$68.65	2024-03-01	Buy
Alfa Aesar	H62771	N-Boc-N-methyl-L-valine, 95%	45170-31-8	5g	$292.65	2024-03-01	Buy
Usbiological	264718	Boc-N-methyl-L-valine	45170-31-8	500mg	$333	2021-12-16	Buy

Product number	Packaging	Price	Buy
8.53085	5G	$135	Buy
15538	1g	$39.44	Buy
H62771	1g	$68.65	Buy
H62771	5g	$292.65	Buy
264718	500mg	$333	Buy

Boc-N-Me-Val-OH Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

N-Boc-N-methyl-L-valine (Boc-N-Me-Val-OH) is an amino acid derived compound that functions as a useful pharmaceutical intermediate and also employed as a reagent used in organic synthesis. It is used in the synthesis of lactam analog of actinomycin D, a potential antitumor chemotherapeutic agent. It is also used to N-tert-Butoxycarbonyl-N-methyl-L-valine 4-ethynylanilide with 4-ethynylaniline[1].

Synthesis

To a solution of N-BOC-valine 1 (217 mg, 1 mmol) and iodomethane(1.42 g, 10 mmol) in anhydrous tetrahydrofuran (THF,20 mL) was added neat sodium hydride (240 mg, 10 mmol). The reaction mixture was stirred at room temperature for 24 hours. The mixture was then quenched with water (30 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 2 15 mL) and the aqueous solution was acidified to pH 3, after which it was extracted with EtOAc (3 20 mL). The combined organic phase was dried over anhydrous Na2SO4 and evaporated to afford the corresponding Boc-N-Me-Val-OH (thick colorless oil), 99% yield.

References

[1] Masashi Shiotsuki. “Molecular weight dependence of helical conformation of amino acid-based polyphenylacetylenes.” Journal of Polymer Science Part A: Polymer Chemistry 49 22 (2011): 4921–4925.

Boc-N-Me-Val-OH synthesis

Synthesis of Boc-N-Me-Val-OH from N-Boc-L-valine and Iodomethane

Boc-N-Me-Val-OH Preparation Products And Raw materials

Raw materials

N-Boc-L-valine NSC 135130 S-Boc-2-mercapto-4,6-dimethylpyrimidine BOC-VAL-OME H-MEVAL-OH HCL

L-Valine methyl ester hydrochloride Di-tert-butyl dicarbonate Dimethyl sulfate Iodomethane L-Valine

tert-butyl azidoformate

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Preparation Products

Boc-N-Me-Val-OH Suppliers

Global( 275)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
WinWin Chemical CO., Limited	+86-0577-64498589 +8615325081899	sales@win-winchemical.com	China	14151	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8615680023009	daisy@enlaibio.com	China	1369	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	274	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58

Supplier	Advantage
WinWin Chemical CO., Limited	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shanghai Getian Industrial Co., LTD	58
Alpha Biopharmaceuticals Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
GenicBio Limited	58

View Lastest Price from Boc-N-Me-Val-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-17	Boc-N-Me-Val-OH 45170-31-8	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-05-15	Boc-N-Me-Val-OH 45170-31-8	US $28.00 / box	1box	99%	20000	Shanghai Getian Industrial Co., LTD
2024-05-10	Boc-N-Me-Val-OH 45170-31-8	US $65.00-650.00 / KG	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd

Boc-N-Me-Val-OH
45170-31-8
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Boc-N-Me-Val-OH
45170-31-8
US $28.00 / box
99%
Shanghai Getian Industrial Co., LTD

Boc-N-Me-Val-OH
45170-31-8
US $65.00-650.00 / KG
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

45170-31-8(Boc-N-Me-Val-OH)Related Search:

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Valine CARBONYL SULFIDE Methyl

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BOC-N-METHYL-L-VAL-OH N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-VALINE NALPHA-tert-Butoxycarbonyl-N-methyl-L-valine N-[(tert-Butoxy)carbonyl]-N-methyl-L-valine (S)-2-((tert-Butoxycarbonyl)(Methyl)aMino)-3-Methylbutanoic acid Boc-N-Me-Val-OH >=99.0% (TLC) Boc-N-Me-L-Val-OH (2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid BOC-N-METHYL-L-VALINE BOC-N-ME-VALINE BOC-MEVAL-OH BOC-N-ALPHA-METHYL-L-VALINE BOC-L-MEVAL-OH N-ALPHA-T-BOC-N-ALPHA-METHYL-L-VALINE N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-VALINE N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE N-BOC-N-METHYL-(L)-VALINE Boc-N-methyl-L-valine≥ 99% (TLC) (Tert-Butoxy)Carbonyl N-Me-Val-OH (Syrup) N-(tert-Butoxycarbonyl)-N-methyl-L-valine> (S)-2-((tert-ButoxycarbonyL )amino)-3-methyL L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- (2S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoicaci Boc-N-methyl-L-valine USP/EP/BP N-Boc-N-methylvaline Boc-N-me-Val BOC-N-ME-VAL-OH Boc-L-N-Me-Val-OH Boc-N-α-Methyl-L-valine Entecavir Impurity 133 45170-31-8 N-Methyl Amino Acids Peptide Synthesis Unnatural Amino Acid Derivatives Specialty Synthesis amino acids Valine [Val, V] N-Methyl Amino Acids Boc-Amino acid series