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Methyl 3-aminocrotonate

Methyl 3-aminocrotonate structure

CAS No.: 14205-39-1

Chemical Name:: Methyl 3-aminocrotonate

Synonyms: Methyl (Z)-3-Aminobut-2-enoate;3-Aminocrotonate;(Z)-Methyl 3-aMinobut-2-enoate;methyl (E)-3-aminobut-2-enoate;3-Amino-but-2-enoic acid methyl ester;PALO-012;Nifedipine-4;Methyl 3-aminocroton;Methyl 3-aminocrotote;Nifedipine Impurity 5

CBNumber:: CB2222855

Molecular Formula:: C5H9NO2

Molecular Weight:: 115.13

MDL Number:: MFCD00071534

MOL File:: 14205-39-1.mol

MSDS File:: SDS

Last updated:2024-04-15 15:30:59

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Methyl 3-aminocrotonate Properties

Melting point	81-83 °C(lit.)
Boiling point	112°C 42mm
Density	1.1808 (rough estimate)
vapor pressure	2.79-2.853hPa at 25℃
refractive index	1.4538 (estimate)
Flash point	91 °C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	18g/l
pka	5.27±0.70(Predicted)
form	Crystalline Powder
color	White to slightly yellow
PH	8-9 (18g/l, H2O, 20℃)
Water Solubility	insoluble
Sensitive	Hygroscopic
BRN	956592
InChIKey	XKORCTIIRYKLLG-ONEGZZNKSA-N
LogP	-0.27 at 25℃
CAS DataBase Reference	14205-39-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	D0M0GH0040
EPA Substance Registry System	2-Butenoic acid, 3-amino-, methyl ester (14205-39-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H317-H318

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

37/39-26-24/25

WGK Germany

RTECS

EM9092500

TSCA

Yes

HS Code

29224995

NFPA 704

	1
2		0

Methyl 3-aminocrotonate price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	129712	Methyl 3-aminocrotonate 97%	14205-39-1	100g	$54.6	2024-03-01	Buy
Sigma-Aldrich	129712	Methyl 3-aminocrotonate 97%	14205-39-1	500g	$54.8	2024-03-01	Buy
TCI Chemical	A1001	Methyl 3-Aminocrotonate >98.0%(T)	14205-39-1	25g	$16	2024-03-01	Buy
TCI Chemical	A1001	Methyl 3-Aminocrotonate >98.0%(T)	14205-39-1	500g	$90	2024-03-01	Buy
Alfa Aesar	B24953	Methyl 3-aminocrotonate, 97%	14205-39-1	500g	$95.3	2024-03-01	Buy

Product number	Packaging	Price	Buy
129712	100g	$54.6	Buy
129712	500g	$54.8	Buy
A1001	25g	$16	Buy
A1001	500g	$90	Buy
B24953	500g	$95.3	Buy

Methyl 3-aminocrotonate Chemical Properties,Uses,Production

Chemical Properties

Crystals, yellowish-white

Uses

Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.

Uses

Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet

Uses

Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.

Preparation

3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.

General Description

Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.

Flammability and Explosibility

Not classified

Methyl 3-aminocrotonate synthesis

Synthesis of Methyl 3-aminocrotonate from Methyl acetoacetate

Methyl 3-aminocrotonate Preparation Products And Raw materials

Raw materials

Preparation Products

Benidipine Cilnidipine Isradipine Nitrendipine Felodipine

Manidipine Nisoldipine Amlodipine Phthaloyl amlodipine Lercanidipine hydrochloride

2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL- Methyl 6-chloro-2-Methylnicotinate 4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid Felodipine 3,5-DiMethyl Ester 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide

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Methyl 3-aminocrotonate Suppliers

Global( 567)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1111	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Methyl 3-aminocrotonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-15	Methyl 3-aminocrotonate 14205-39-1	US $0.00 / kg	1kg	99%	10000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2023-09-04	Methyl 3-aminocrotonate 14205-39-1	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-07-31	Methyl 3-aminocrotonate 14205-39-1	US $5.00 / kg	10kg	99%	20tons	Hebei Linwo New Material Technology Co., LTD

Methyl 3-aminocrotonate
14205-39-1
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Methyl 3-aminocrotonate
14205-39-1
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Methyl 3-aminocrotonate
14205-39-1
US $5.00 / kg
99%
Hebei Linwo New Material Technology Co., LTD

Methyl 3-aminocrotonate Spectrum

Methyl 3-aminocrotonate(14205-39-1)MS Methyl 3-aminocrotonate(14205-39-1)¹HNMR Methyl 3-aminocrotonate(14205-39-1)¹³CNMR Methyl 3-aminocrotonate(14205-39-1)IR1 Methyl 3-aminocrotonate(14205-39-1)IR2 Methyl 3-aminocrotonate(14205-39-1)Raman

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METHYL-BETA-AMINOCROTONATE METHYL 4-AMINOCROTONATE METHYL 3-AMINOCROTONATE METHYL 3-AMINO-2-BUTENOATE AMINOCROTONIC ACID METHYL ESTER 3-AMINOCROTONATE METHYL ESTER 3-AMINOCROTONIC ACID METHYL ESTER 3-AMINO-2-BUTENOIC ACID METHYL ESTER 3-amino-2-butenoicacimethylester 3-amino-crotonicacimethylester beta-Iminomethylbutyrate beta-aminocrotonicacidmethylester methyl3-aminocrotonoate methyl 3-amino-trans-but-2-enoate 2-Butenoic acid, 3-amino-, methyl ester Methyl β-aminobutenate Methyl 3-iminobutyrate Crotonic acid, 3-amino-, methyl ester (1-Aminoethylidene)acetic acid methyl 3-Amino-2-butenoic acid methyl Methyl 3-aminocrotonate,97% Methyl 3-aminocroton Methyl 3-aMinocrotonate, 97% 100GR Methyl 3-aMinocrotonate, 97% 500GR Methyl 3-AMino-2-butenenoate 3-Amino-2-butenoic Acid Methyl Ester 3-Aminocrotonic Acid Methyl Ester Methyl 3-Amino-2-butenoate Methyl 3-aminocrotonate 97% Methyl 3-Aminocrotonate Methyl 3-Amino-2-butenoate 3-Amino-2-butenoic Acid Methyl Ester Methyl 3-aminocrotote Divalproex Sodium Impurity 4 Nifedipine-4 3-Methyl 3-aminocrotonate Nifedipine Impurity D Control Methyl 3-aminocrotonate fiona Methyl3-Aminocrotonate> -amino-methyl cromarate Nifedipine Impurity 16 (Methyl 3-aminocrotonate) MEHYL 3-AMINOCROTONATE Azilsartan medoxomil impurity305 Nifedipine impurity D (EP) PALO-012 Nifedipine Impurity 5 3-Amino-but-2-enoic acid methyl ester (Z)-Methyl 3-aMinobut-2-enoate methyl (E)-3-aminobut-2-enoate Methyl (Z)-3-Aminobut-2-enoate 3-Aminocrotonate Methyl Β-Aminobutenate Methy1 3-aminocrotonate 14205-39-1 14205-23-0 14205-34-1 14205-79-1 CH3CNH2CHCOOCH3 Aromatic Amino Acids C2 to C5 Carbonyl Compounds Building Blocks