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2'-O-Methylguanosine

2'-O-Methylguanosine structure

CAS No.: 2140-71-8

Chemical Name:: 2'-O-Methylguanosine

Synonyms: 2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe Guanosine;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methylguanosine;2 '- Methoxyguanosine;2'-O-Methyl-D-guanosine;Guanosine, 2'-O-methyl-

CBNumber:: CB2276641

Molecular Formula:: C11H15N5O5

Molecular Weight:: 297.27

MDL Number:: MFCD00057053

MOL File:: 2140-71-8.mol

MSDS File:: SDS

Last updated:2023-11-24 17:41:42

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2'-O-Methylguanosine Properties

Melting point	227-231°C (dec.)
Density	1.98±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Aqueous Base (Slightly), DMSO (Slightly),
pka	9?+-.0.20(Predicted)
form	Powder
color	White to Off-white
InChI	InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1
InChIKey	OVYNGSFVYRPRCG-KQYNXXCUSA-N
SMILES	OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O
CAS DataBase Reference	2140-71-8(CAS DataBase Reference)
FDA UNII	W722H4PA1S

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38-22

Safety Statements

26-36-60-36/37

HS Code

29349990

NFPA 704

	0
2		0

2'-O-Methylguanosine price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2318	2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T)	2140-71-8	1g	$280	2024-03-01	Buy
TCI Chemical	M2318	2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T)	2140-71-8	200mg	$89	2024-03-01	Buy
Alfa Aesar	J65770	2'-O-Methylguanosine, 99%	2140-71-8	1g	$82.4	2024-03-01	Buy
Alfa Aesar	J65770	2'-O-Methylguanosine 99%	2140-71-8	250mg	$20.2	2021-12-16	Buy
Cayman Chemical	21039	2'-O-Methylguanosine ≥98%	2140-71-8	250mg	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
M2318	1g	$280	Buy
M2318	200mg	$89	Buy
J65770	1g	$82.4	Buy
J65770	250mg	$20.2	Buy
21039	250mg	$57	Buy

2'-O-Methylguanosine Chemical Properties,Uses,Production

Description

2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

Chemical Properties

White Solid

Uses

Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.

Synthesis

8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.

2'-O-Methylguanosine synthesis

Synthesis of 2'-O-Methylguanosine from Triethylenediamine and 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside

2'-O-Methylguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-O-Methylguanosine Suppliers

Global( 237)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Zhengzhou Chemprize Biotech Co., Ltd.	+86-86-0371-56768238 +8615981919713	sales@chemprize.com	China	297	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

Supplier	Advantage
Wuhu Nuowei chemistry Co., Ltd.	58
Yunbio Tech Co.,Ltd.	58
Zhengzhou Chemprize Biotech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 2'-O-Methylguanosine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-02-06	2'-O-Methylguanosine 2140-71-8	US $0.00 / KG	1KG	98%	300KG per month	Yunbio Tech Co.,Ltd.
2023-05-12	2'-O-Methylguanosine 2140-71-8	US $0.00 / g	1g	98%	100kg	Hefei Huana Biomedical Technology Co.,Ltd.
2023-04-04	2'-O-Methylguanosine 2140-71-8	US $0.00-0.00 / kg	1kg	98%	500kg per month	Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-O-Methylguanosine
2140-71-8
US $0.00 / KG
98%
Yunbio Tech Co.,Ltd.

2'-O-Methylguanosine
2140-71-8
US $0.00 / g
98%
Hefei Huana Biomedical Technology Co.,Ltd.

2'-O-Methylguanosine
2140-71-8
US $0.00-0.00 / kg
98%
Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-O-Methylguanosine Spectrum

2'-O-Methylguanosine(2140-71-8)¹HNMR

2140-71-8(2'-O-Methylguanosine)Related Search:

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7,8-Dihydro-7-methylguanosine 2',3'-O-Isopropylideneguanosine 2',3',5'-Triacetylguanosine 1-METHYLGUANOSINE N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N2-Isobutyryl-2'-O-Methyl-guanosine 2'-O-Methyl-N2-dimethylformamide-5'-O-DMT-Guanosine 2-Methylguanosine,N2-METHYLGUANOSINE,N-Methylguanosine N2-dimethylformamidine-2'-O-Methyl-guanosine 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine

2'-C-Methylguanosine 2'-(N-Methylanthraniloyl)guanosine 3',5'-Cyclicmonophosphate, Sodium Salt 2',3',5-TRI-O-ACETYL-8-BROMOGUANOSINE

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2'-OMe-G 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one 2-azanyl-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]-3H-purin-6-one 2'-OMe Guanosine 2'-O-METHYLGUANOSINE 2'-O-Methyl-D-guanosine 2'-O-Methyl Guanosine, >=99% 2-aMino-9-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one 2'-O-Methylguanosine Hydrate 2'-OMe-Gr 2'-O-MethylguanosineHydrate> Guanosine, 2'-O-methyl- 2'-OMe-rG 2'-O-Methylguanosine USP/EP/BP 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one 2’-O-Methylguanosine,RNA modified nucleoside Gm Apoptosis,2’ OMe Guanosine,rRNA,inhibit,2’OMeGuanosine,Inhibitor,Nucleoside Antimetabolite/Analog,tRNA 2 '- Methoxyguanosine 2'-O-Methylguanosine 2'-OMe Guanosine 2140-71-8 C11H15N5O5xH2O C11H15N5O5H2O Nucleotides Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-OMe Nucleosides