Brompheniramine hydrogen maleate
- CAS No.
- 980-71-2
- Chemical Name:
- Brompheniramine hydrogen maleate
- Synonyms
- dimegan;dimotane;dimetane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate;BROMPHENIRAMINE MALEATE
- CBNumber:
- CB2736194
- Molecular Formula:
- C20H23BrN2O4
- Molecular Weight:
- 435.31
- MDL Number:
- MFCD00057367
- MOL File:
- 980-71-2.mol
| Melting point | 134-135°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| color | White to Off-White |
| λmax | 261nm(lit.) |
| Merck | 14,1443 |
| Stability | Hygroscopic |
| InChIKey | SRGKFVAASLQVBO-BTJKTKAUSA-N |
| LogP | 3.565 (est) |
| FDA 21 CFR | 341.12 |
| CAS DataBase Reference | 980-71-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | IXA7C9ZN03 |
| EPA Substance Registry System | 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi,T,F | |||||||||
| Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US4025000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 38220090 | |||||||||
| NFPA 704 |
|
Brompheniramine hydrogen maleate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B-043 | Brompheniramine maleate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 980-71-2 | 1mL | $50 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1078008 | (±)-Brompheniramine maleate salt | 980-71-2 | 125mg | $358 | 2024-03-01 | Buy |
| TCI Chemical | B5167 | Brompheniramine Maleate >98.0%(HPLC)(T) | 980-71-2 | 25g | $91 | 2024-03-01 | Buy |
| Alfa Aesar | J63922 | Brompheniramine maleate | 980-71-2 | 25mg | $85.65 | 2024-03-01 | Buy |
| Alfa Aesar | J63922 | Brompheniramine maleate | 980-71-2 | 100mg | $249 | 2021-12-16 | Buy |
Brompheniramine hydrogen maleate Chemical Properties,Uses,Production
Description
Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.
Chemical Properties
White Solid
Originator
Dimetane,Robins,US,1957
Uses
An antihistamine and also an inhibitor of serotonin reuptake
Uses
This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.
Uses
Antihistaminic;H1 Antagonist
Definition
ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Manufacturing Process
Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.
brand name
Dimetane (Wyeth).
Therapeutic Function
Antihistaminic
General Description
Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
Side effects
The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.
Brompheniramine hydrogen maleate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3335 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9335 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from Brompheniramine hydrogen maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-14 | Brompheniramine Maleate
980-71-2
|
US $0.00 / kg | 1kg | 99.76% | 20tons | Wuhan Han Sheng New Material Technology Co.，Ltd | |
 |
2023-04-18 | Brompheniramine hydrogen maleate
980-71-2
|
US $50.00 / kg | 1kg | 99% | 30 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-07-20 | Brompheniramine hydrogen maleate
980-71-2
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Brompheniramine Maleate
980-71-2
- US $0.00 / kg
- 99.76%
- Wuhan Han Sheng New Material Technology Co.，Ltd
-
- Brompheniramine hydrogen maleate
980-71-2
- US $50.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Brompheniramine hydrogen maleate
980-71-2
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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