17-AAG (Hydrochloride)
- CAS No.
- 911710-03-7
- Chemical Name:
- 17-AAG (Hydrochloride)
- Synonyms
- 17-AAG (Hydrochloride);CP 127374 Hydrochloride;NSC 330507 Hydrochloride;Tanespimycin (17-AAG) HCl;TanespiMycin Hydrochloride;Tanespimycin (17-AAG) hydrochloride;17-(Allylamino)-17-desmethylgeldanamycin hydrochloride;TANESPIMYCIN HYDROCHLORIDE;NSC 330507 HYDROCHLORIDE;CP 127374 HYDROCHLORIDE;17AAG HYDROCHLORIDE;17 AAG HYDROCHLORIDE;(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate hydrochloride
- CBNumber:
- CB32623729
- Molecular Formula:
- C31H44ClN3O8
- Molecular Weight:
- 622.16
- MDL Number:
- MOL File:
- 911710-03-7.mol
17-AAG (Hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611525 | 17-AAG hydrochloride | 911710-03-7 | 100mg | $397.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611525 | 17-AAG hydrochloride | 911710-03-7 | 250mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611525 | 17-AAG hydrochloride | 911710-03-7 | 1g | $912.9 | 2021-12-16 | Buy |
| DC Chemicals | DC22630 | 17-AAGhydrochloride >98% | 911710-03-7 | 1g | $600 | 2021-12-16 | Buy |
| Crysdot | CD31000304 | 17-AAGHydrochloride 98+% | 911710-03-7 | 10mg | $49 | 2021-12-16 | Buy |
17-AAG (Hydrochloride) Chemical Properties,Uses,Production
Description
17-AAG Hydrochloride is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
in vitro
In Vitro:17-AAG causes the degradation of HER2, Akt, and both mutant and wild-type AR and the retinoblastoma-dependent G1 growth arrest of prostate cancer cells. 17-AAG inhibits prostate cancer cell lines with IC50s ranged from 25-45 nM (LNCaP, 25 nM; LAPC-4, 40 nM; DU-145, 45 nM; and PC-3, 25 nM)[1]. Combination of 17-AAG (10 nM) and Trastuzumab induces more effective ErbB2-degradation. 17-AAG (0.1-1 μM) induces a nearly complete loss of ErbB2 on ErbB2-overexpressing breast cancer cells[2]. 17-AAG inhibits cell growth and induces G2/M cell cycle arrest and apoptosis in CCA cells together with the down-regulation of Bcl-2, Survivin and Cyclin B1, and the up-regulation of cleaved PARP[3].
in vivo
In Vivo:17-AAG (25-200 mg/kg, i.p.) causes a dose-dependent decline in AR, HER2, and Akt expression in prostate cancer xenografts. 17-AAG treatment at doses sufficient to induce AR, HER2, and Akt degradation results in the dose-dependent inhibition of androgen-dependent and -independent prostate cancer xenograft growth without toxicity[1]. 17-AAG (60 mg/kg) with paclitaxel (60 mg/kg) and rapamycin (30 mg/kg) inhibits A549 and MDA-MB-231 tumor growth far more potently than paclitaxel-containing micelles and effected tumor cures in MDA-MB-231 tumor-bearing animals by tail vein injection[4].
References
References:[1]. Solit DB, et al. 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.Clin Cancer Res, 2002, 8(5), 986-993. [2]. Raja, Srikumar M., et al. A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells. Cancer Biology & Therapy (2008), 7(10), 163 [3]. Zhang J, et al. The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.Clin Exp Med. 2012 Sep 7. [4]. Newman B, et al. HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells.Cancer Res. 2012 Sep 1;72(17):4551-61. Epub 2012 Jun 29. [5]. Kamal A, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003 Sep 25;425(6956):407-10.
17-AAG (Hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
17-AAG (Hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9452 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9771 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31163 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |