Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>MK 0557

MK 0557

MK 0557 Structure
MK 0557 structure
CAS No.
328232-95-7
Chemical Name:
MK 0557
Synonyms
MK 0557;CS-2471;MK0557;MK 0557;MK0557,Neuropeptide Y Receptor,inhibit,MK 0557,Inhibitor,NPY receptor,MK-0557;N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester;N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide;trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide;trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
CBNumber:
CB32628133
Molecular Formula:
C22H19FN4O3
Molecular Weight:
406.41
MDL Number:
MFCD25976714
MOL File:
328232-95-7.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
Request For Quotation

MK 0557 Properties

Melting point 240.0-240.6 °C
Boiling point 708.7±60.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
form A crystalline solid
pka 13.40±0.20(Predicted)
FDA UNII HVE36P8422

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

MK 0557 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22134 MK-0557 ≥98% 328232-95-7 1mg $37 2024-03-01 Buy
Cayman Chemical 22134 MK-0557 ≥98% 328232-95-7 5mg $161 2024-03-01 Buy
Cayman Chemical 22134 MK-0557 ≥98% 328232-95-7 10mg $283 2024-03-01 Buy
Cayman Chemical 22134 MK-0557 ≥98% 328232-95-7 25mg $618 2024-03-01 Buy
ChemScene CS-6367 MK-0557 99.76% 328232-95-7 50mg $792 2021-12-16 Buy
Product number Packaging Price Buy
22134 1mg $37 Buy
22134 5mg $161 Buy
22134 10mg $283 Buy
22134 25mg $618 Buy
CS-6367 50mg $792 Buy

MK 0557 Chemical Properties,Uses,Production

Description

MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.

MK 0557 Preparation Products And Raw materials

Raw materials

Preparation Products

MK 0557 Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765 zxx@hktiansheng.com China 981 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33350 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Supplier Advantage
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Hong Kong Tiansheng New Material Trading Co., Ltd 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55

View Lastest Price from MK 0557 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK 0557 pictures 2022-02-25 MK 0557
328232-95-7
 US $100.00 / KG 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide pictures 2022-02-25 N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
328232-95-7
 US $100.00 / Kg/Bag 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide pictures 2019-12-23 trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
328232-95-7
 US $1.00 / KG 1KG 99% 100KG Career Henan Chemical Co
  • MK 0557 pictures
  • MK 0557
    328232-95-7
  • US $100.00 / KG
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

328232-95-7(MK 0557)Related Search:

MK-2206 2HCl MK-5172 Mk-2461 . (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Omarigliptin (MK-3102)
MK-8998 MK-4101 MK8745 mk-1064 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
MK-0812 (Succinate) MKC9989 MK-1775 SCH900776 MK-0752
MKC3946 MK-3903

1of4

MK 0557 trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide (1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans- MK0557;MK 0557 CS-2471 N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester MK0557,Neuropeptide Y Receptor,inhibit,MK 0557,Inhibitor,NPY receptor,MK-0557 trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide 328232-95-7 28232-95-7