WH-4-023
- CAS No.
- 837422-57-8
- Chemical Name:
- WH-4-023
- Synonyms
- KIN112;CS-1827;WH-4-023;WH-4-024;KIN001-112;WH-4-023, >=98%;)(2-((4-(4-methyL;WH-4-023 USP/EP/BP;WH-4-023, 837422-57-8;)amino)pyrimidin-4-yL
- CBNumber:
- CB32710784
- Molecular Formula:
- C32H36N6O4
- Molecular Weight:
- 568.67
- MDL Number:
- MFCD28138072
- MOL File:
- 837422-57-8.mol
- MSDS File:
- SDS
| Boiling point | 743.2±70.0 °C(Predicted) |
|---|---|
| Density | 1.247±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (60 mg/ml) |
| pka | 7.89±0.42(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| NFPA 704 |
|
WH-4-023 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1334 | WH-4-023 ≥98% (HPLC) | 837422-57-8 | 5mg | $146 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1334 | WH-4-023 ≥98% (HPLC) | 837422-57-8 | 25mg | $564 | 2023-01-07 | Buy |
| Cayman Chemical | 9002067 | WH-4-023 ≥98% | 837422-57-8 | 1mg | $39 | 2024-03-01 | Buy |
| Cayman Chemical | 9002067 | WH-4-023 ≥98% | 837422-57-8 | 5mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 9002067 | WH-4-023 ≥98% | 837422-57-8 | 10mg | $172 | 2024-03-01 | Buy |
WH-4-023 Chemical Properties,Uses,Production
Description
WH-4-23 (837422-57-8) is a potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively.1,2 Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively.3 May be used along with PD-325901 and CHIR-99021 to support self-renewal of na?ve human embryonic stem cells.4
Uses
WH-4-023 is a potent and selective dual lymphocyte-specific kinase (Lck) inhibitor.
Definition
ChEBI: N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester is a member of piperazines.
Biochem/physiol Actions
WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).
storage
Store at -20°C
References
Martin et al. (2006), Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity; J. Med. Chem., 49 4981 Moroco et al. (2015), A discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region; Chem. Biol. Drug. Des., 86 144 Clark et al. (2012), Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages; Proc. Natl. Acad. Sci. USA, 109 16986 Theunissen et al. (2014), Systemic identification of culture conditions for introduction and maintenance of na?ve human pluripotency; Cell Stem Cell, 15 471
WH-4-023 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27894 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13040 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
View Lastest Price from WH-4-023 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-05 | 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
837422-57-8
|
US $1.00 / ASSAYS | 1ASSAYS | 96% | 10kg | Career Henan Chemical Co |
-
- 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
837422-57-8
- US $1.00 / ASSAYS
- 96%
- Career Henan Chemical Co
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