2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
- CAS No.
- 1217766-70-5
- Chemical Name:
- 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
- Synonyms
- [2H3]-Ketoconazole;Ketoconazole (acetyl-d3);2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;Ketoconazole D3Q: What is Ketoconazole D3 Q: What is the CAS Number of Ketoconazole D3 Q: What is the storage condition of Ketoconazole D3 Q: What are the applications of Ketoconazole D3
- CBNumber:
- CB33809142
- Molecular Formula:
- C26H28Cl2N4O4
- Molecular Weight:
- 531.43
- MDL Number:
- MOL File:
- 1217766-70-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS08,GHS09 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H360-H373-H400-H410 | |||||||||
Precautionary statements | P201-P202-P260-P264-P270-P273-P280-P301+P310-P321-P330-P308+P313-P314-P391-P405-P501 | |||||||||
NFPA 704 |
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2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10010656 | Ketoconazole-d3 | 1217766-70-5 | 1mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 10010656 | Ketoconazole-d3 | 1217766-70-5 | 5mg | $275 | 2024-03-01 | Buy |
Cayman Chemical | 10010656 | Ketoconazole-d3 | 1217766-70-5 | 500μg | $32 | 2024-03-01 | Buy |
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Chemical Properties,Uses,Production
Description
Ketoconazole-d3 is intended for use as an internal standard for the quantification of ketoconazole by GC- or LC-MS. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 μg/ml).1 It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 μM). Formulations containing ketoconazole have been used in the treatment of fungal infections.
Uses
Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.
References
1. Dilmaghanian, S., Gerber, J.G., Filler, D.G., et al. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates Chirality 16(2),79-85(2004).
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | info@synzest.com | China | 9287 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
Manhag Testing Technology Co., Ltd | 020-020-3846236 17688849268 | 2443244976@qq.com | China | 7775 | 58 |
QUALITY CONTROL SOLUTIONS LTD. | 13670046396 | ORDERS@QCSRM.COM | China | 18820 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12584 | 58 |
1217766-70-5(2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone)Related Search:
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