tolpropamine hydrochloride
- CAS No.
- 3339-11-5
- Chemical Name:
- tolpropamine hydrochloride
- Synonyms
- Tolpropamine HCl;Einecs 222-082-9;tolpropamine hydrochloride;tolpropamine hydrochloride USP/EP/BP
- CBNumber:
- CB3875256
- Molecular Formula:
- C18H23N.ClH
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| Melting point | 162-164 °C |
|---|---|
| FDA UNII | 1P6C450YET |
tolpropamine hydrochloride Chemical Properties,Uses,Production
Originator
Tolpropamine,Hoechst (Aventis)
Manufacturing Process
The Grignard solution (prepared from 53 g bromtoluene and 7.2 g magnesium
in 300 ml of ether) was added dropwise to a solution of 35 g β-
dimethylaminopropiophenone in 50 ml ether. The mixture was refluxed for 3
hours. Then the liquid phase was added to 500 parts of ice and 100 parts
concentrated hydrochloric acid. 1-Phenyl-1-p-tolyl-3-dimethylaminopropanol-1
was crystallized. M.P. of hydrochloride of 1-phenyl-1-p-tolyl-3-
dimethylaminopropanol-1 185°C.
10 g of 1-phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was dissolved in 30 ml
of 85% phosphoric acid and the solution was heated at 130-135°C for 1 hour.
After cooling to the mixture was added a water and an aqueous solution of
sodium hydroxide. γ-Phenyl-γ-p-tolylallyldimethylamine was extracted with
ether and extract was dried with sodium sulfate.
γ-Phenyl-γ-p-tolylallyldimethylamine hydrochloride was hydrogenated with
palladium catalyst. γ-Phenyl-γ-p-tolyl-3-dimethylaminopropan obtained has
melting point 156°C.
Therapeutic Function
Antihistaminic, Antipruritic
tolpropamine hydrochloride Preparation Products And Raw materials
tolpropamine hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27644 | 58 |
| Supplier | Advantage |
|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| Dideu Industries Group Limited | 58 |
View Lastest Price from tolpropamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-18 | tolpropamine hydrochloride USP/EP/BP
3339-11-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- tolpropamine hydrochloride USP/EP/BP
3339-11-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited