ChemicalBook >> CAS DataBase List >>avosentan
avosentan
- CAS No.
- 290815-26-8
- Chemical Name:
- avosentan
- Synonyms
- CS-644;SPP-301;avosentan;Ro 67-0565;Avosentan (SPP301);RO 67-0565; SPP-301;Avosentan (Ro 67-0565;avosentan,CID 9912992;inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor;N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam
- CBNumber:
- CB41508589
- Molecular Formula:
- C23H21N5O5S
- Molecular Weight:
- 479.51
- MDL Number:
- MFCD23843806
- MOL File:
- 290815-26-8.mol
Last updated:2023-09-04 15:51:00
Boiling point | 575.5±60.0 °C(Predicted) |
---|---|
Density | 1.363 |
storage temp. | Store at -20°C |
solubility | DMSO : 6.67 mg/mL (13.91 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
form | Powder |
pka | 3.19±0.10(Predicted) |
FDA UNII | L94KSX715K |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264-P270-P301+P312-P330-P501 |
avosentan price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A794710 | Avosentan | 290815-26-8 | 10mg | $165 | 2021-12-16 | Buy |
Usbiological | 002983 | Avosentan | 290815-26-8 | 10mg | $460 | 2021-12-16 | Buy |
ChemScene | CS-0625 | Avosentan 98.36% | 290815-26-8 | 10mg | $180 | 2021-12-16 | Buy |
Matrix Scientific | 098678 | N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide 95+% | 290815-26-8 | 250mg | $742 | 2021-12-16 | Buy |
ChemScene | CS-0625 | Avosentan 98.36% | 290815-26-8 | 50mg | $840 | 2021-12-16 | Buy |
avosentan Chemical Properties,Uses,Production
Uses
Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.
Enzyme inhibitor
This potent, selective and orally available endothelin A receptor blocker (FW = 479.51 g/mol; CAS 290815-26-8; Soluble in DMSO), also known by its code names SPP301 and Ro 67-0565, induces the dose-dependent reduction in the fractional renal excretion of sodium (up to 8.7% at 50 mg avosentan), with a paralleled dose-related increase in proximal sodium reabsorption. Avosentan reduces albuminuria, when added to standard treatment in patients with type 2 diabetes and overt nephropathy, but induces significant fluid overload and congestive heart failure.
avosentan Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 67)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6010 | 61 |
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
290815-26-8(avosentan)Related Search:
N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam
2-Pyridinesulfonamide,N-[6-methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-
avosentan
N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide
Ro 67-0565
SPP-301
Avosentan (SPP301)
CS-644
Avosentan (Ro 67-0565
RO 67-0565; SPP-301
avosentan,CID 9912992
inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor
290815-26-8
C23H21N5O5S