D-erythro-C18-Dihydro-D-sphingosine
- CAS No.
- 764-22-7
- Chemical Name:
- D-erythro-C18-Dihydro-D-sphingosine
- Synonyms
- (2S,3R)-;SPC-102860;SPHINGANINE;Sphinganine (d18:0);D-erythro-sphinganine;Dihydro-D-erythro-Sphingosine;D-ERYTHRO-DIHYDRO-D-SPHINGOSINE;(2S,3R)-2-aminooctadecane-1,3-diol;(2S,3R)-2-azanyloctadecane-1,3-diol;D-erythro-C18-Dihydro-D-sphingosine
- CBNumber:
- CB42130435
- Molecular Formula:
- C18H39NO2
- Molecular Weight:
- 301.51
- MDL Number:
- MFCD07371371
- MOL File:
- 764-22-7.mol
- MSDS File:
- SDS
| Melting point | 70-72°C |
|---|---|
| Boiling point | 446.2±25.0 °C(Predicted) |
| Density | 0.927±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble25mg/mL (warm) |
| pka | 12.57±0.45(Predicted) |
| form | White to off-white solid. |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| EWG's Food Scores | 1 |
| FDA UNII | YT0ZSD64HM |
D-erythro-C18-Dihydro-D-sphingosine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D3314 | D-erythro-Dihydrosphingosine ≥98% | 764-22-7 | 10mg | $117 | 2024-03-01 | Buy |
| Sigma-Aldrich | D3314 | D-erythro-Dihydrosphingosine ≥98% | 764-22-7 | 50mg | $527 | 2024-03-01 | Buy |
| Cayman Chemical | 10007945 | Sphinganine (d18:0) ≥98% | 764-22-7 | 5mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 10007945 | Sphinganine (d18:0) ≥98% | 764-22-7 | 10mg | $66 | 2024-03-01 | Buy |
| Cayman Chemical | 10007945 | Sphinganine (d18:0) ≥98% | 764-22-7 | 25mg | $155 | 2024-03-01 | Buy |
D-erythro-C18-Dihydro-D-sphingosine Chemical Properties,Uses,Production
Description
Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1?and phospholipases A2 and D2.
Chemical Properties
White Powder
Uses
Sphinganine (d18:0) has been used:
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
- as a medium supplement to test its effect on growth of yeast cells
- in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition
Uses
Biosynthetic precursor of Sphingosine. Inhibits protein kinase C.
Definition
ChEBI: Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a human metabolite and a mouse metabolite. It is a conjugate base of a sphinganine(1+).
General Description
Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.
Biochem/physiol Actions
Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.
References
1) Merrill?et al. (1989),?Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for cellular effects of these compounds; Biochemistry,?28?3138 2) Franson?et al. (1992),?Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine, Biochim. Biophys. Acta?1136?169
D-erythro-C18-Dihydro-D-sphingosine Preparation Products And Raw materials
Raw materials
Preparation Products
D-erythro-C18-Dihydro-D-sphingosine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 | lchen@syncozymes.com | China | 188 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Renshi Pharmatech Co., LTD | 021-61150625 17721318029 | info@renshipharma.com | China | 113 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Syncozymes (Shanghai) Co.,Ltd. | 021-68187180-819 13681683526 | lchen@syncozymes.com | China | 191 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |