2-chloro-4-iodopyrimidine
- CAS No.
- 395082-55-0
- Chemical Name:
- 2-chloro-4-iodopyrimidine
- Synonyms
- 2-chloro-4-iodopyrimidine;Pyrimidine, 2-chloro-4-iodo-
- CBNumber:
- CB42617534
- Molecular Formula:
- C4H2ClIN2
- Molecular Weight:
- 240.43
- MDL Number:
- MOL File:
- 395082-55-0.mol
| Melting point | 111.3-112.4 °C |
|---|---|
| Boiling point | 317.8±15.0 °C(Predicted) |
| Density | 2.187±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -2.88±0.20(Predicted) |
| InChI | InChI=1S/C4H2ClIN2/c5-4-7-2-1-3(6)8-4/h1-2H |
| InChIKey | LOPQDJJEZFCJMU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(I)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-chloro-4-iodopyrimidine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 1994AQ | 2-chloro-4-iodopyrimidine | 395082-55-0 | 100mg | $179.6 | 2021-12-16 | Buy |
| Chemenu | CM252706 | 2-Chloro-4-iodopyrimidine 95% | 395082-55-0 | 1g | $294 | 2021-12-16 | Buy |
| Crysdot | CD11130263 | 2-Chloro-4-iodopyrimidine 95+% | 395082-55-0 | 1g | $311 | 2021-12-16 | Buy |
| Alichem | 395082550 | 2-Chloro-4-iodopyrimidine | 395082-55-0 | 250mg | $898.6 | 2021-12-16 | Buy |
| Crysdot | CD11130263 | 2-Chloro-4-iodopyrimidine 95+% | 395082-55-0 | 5g | $932 | 2021-12-16 | Buy |
2-chloro-4-iodopyrimidine Chemical Properties,Uses,Production
Description
2-Chloro-4-iodopyrimidine is an inhibitor of protein kinases. It binds to the ATP site of a kinase and inhibits its activity by forming a covalent bond with the serine or threonine residue of the active site. 2-Chloro-4-iodopyrimidine has been shown to inhibit tumor cell proliferation and induce apoptosis in vitro and in vivo. This compound has been shown to inhibit the activity of family kinases, including those involved in tumor growth and angiogenesis.
Preparation
The raw material and cuprous iodide are homogeneously mixed in acetonitrile. Add tert-butyl nitroso ester at -2 °C and stir for 5 min to heat the reaction to 73 °C. After 3h of the reaction, the raw material reaction was completed by TLC detection, cooled to room temperature, and water and saturated sodium carbonate solution were added to the reaction. Finally, the product is purified to obtain the product
2-chloro-4-iodopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-4-iodopyrimidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zepeptide Biotechnology (Shijiazhuang) Co., Ltd | +86-86-13383293380 +8613230482270 | 1919301810@qq.com | China | 141 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 41438 | 60 |