Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>KML-29

KML-29

KML-29 Structure
KML-29 structure
CAS No.
1380424-42-9
Chemical Name:
KML-29
Synonyms
KML-29;CS-2396;KML29 (KML-29);KML29;KML-29;KML 29;LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29;1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
CBNumber:
CB42653891
Molecular Formula:
C24H21F6NO7
Molecular Weight:
549.42
MDL Number:
MFCD22987957
MOL File:
1380424-42-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
Request For Quotation

KML-29 Properties

Melting point 204-206°C
Boiling point 554.8±50.0 °C(Predicted)
Density 1.511±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
pka 13.32±0.29(Predicted)
form Solid
color White to Off-White

KML-29 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2166 KML29 ≥98% (HPLC) 1380424-42-9 5mg $64.9 2024-03-01 Buy
Sigma-Aldrich SML2166 KML29 ≥98% (HPLC) 1380424-42-9 25mg $264 2024-03-01 Buy
Cayman Chemical 11777 KML29 ≥98% 1380424-42-9 5mg $61 2024-03-01 Buy
Cayman Chemical 11777 KML29 ≥98% 1380424-42-9 10mg $112 2024-03-01 Buy
Cayman Chemical 11777 KML29 ≥98% 1380424-42-9 50mg $468 2024-03-01 Buy
Product number Packaging Price Buy
SML2166 5mg $64.9 Buy
SML2166 25mg $264 Buy
11777 5mg $61 Buy
11777 10mg $112 Buy
11777 50mg $468 Buy

KML-29 Chemical Properties,Uses,Production

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity. As a second generation MAGL inhibitor, KML29 supersedes the low-level cross reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound.

Uses

KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid.

storage

Store at -20°C

KML-29 Preparation Products And Raw materials

Raw materials

Preparation Products

KML-29 Suppliers

Global( 75)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4664 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Labnetwork lnc. 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Amadis Chemical Company Limited 		58

View Lastest Price from KML-29 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KML-29 pictures 2020-01-13 KML-29
1380424-42-9
 US $0.01 / KG 1KG 98%; 99% 500g； 1kg; 25kg Career Henan Chemical Co
  • KML-29 pictures
  • KML-29
    1380424-42-9
  • US $0.01 / KG
  • 98%; 99%
  • Career Henan Chemical Co
KML-29 KML29;KML-29;KML 29 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester CS-2396 KML29 (KML-29) 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29 1380424-42-9 C24H21F6NO7 Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals