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Sitagliptin N-Boc IMpurity

Sitagliptin N-Boc IMpurity Structure
Sitagliptin N-Boc IMpurity structure
CAS No.
486460-23-5
Chemical Name:
Sitagliptin N-Boc IMpurity
Synonyms
Sitagliptin-3;Boc-Sitagliptin;N-Boc-Sitagliptin;Sitagliptin N-Boc;Sitagliptin Impurity 56;Phenol,3-fluoro-8-iodo-;Sitagliptin Impurity 03;Sitagliptin N-Boc IMpurity;Sitagliptin EP Impurity 16;Sitagliptin N-Boc impurities
CBNumber:
CB42675705
Molecular Formula:
C21H23F6N5O3
Molecular Weight:
507.43
MDL Number:
MOL File:
486460-23-5.mol
Last updated:2023-06-08 09:03:09
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Sitagliptin N-Boc IMpurity Properties

Melting point 188-191 °C(Solv: toluene (108-88-3))
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Slightly)
pka 11.60±0.46(Predicted)
form Solid
color White
FDA UNII C2VCH5A4VG

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H315-H319-H335-H373-H412
Precautionary statements  P260-P264-P270-P271-P273-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P314-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

Sitagliptin N-Boc IMpurity price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B667500 N-Boc-Sitagliptin 486460-23-5 25mg $180 2021-12-16 Buy
Alichem 486460235 (R)-tert-Butyl(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 486460-23-5 5g $816 2021-12-16 Buy
Product number Packaging Price Buy
B667500 25mg $180 Buy
486460235 5g $816 Buy

Sitagliptin N-Boc IMpurity Chemical Properties,Uses,Production

Uses

N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.

Sitagliptin N-Boc IMpurity synthesis

486460-00-8
762240-92-6
486460-23-5
Synthesis of Sitagliptin N-Boc IMpurity from Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid and 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Sitagliptin N-Boc IMpurity Preparation Products And Raw materials

Raw materials

486460-25-7 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
BOC-D-2,4,5-TRIFLUOROPHE 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine 2,4,5-Trifluorobenzyl bromide 1-Bromo-2,4,5-trifluorobenzene tert-Butanol
Di-tert-butyl dicarbonate

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Preparation Products

Sitagliptin N-Boc IMpurity Suppliers

Global( 102)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 info@afinechem.com China 15396 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12382 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		+86-029-86185165 +8618629664246 guoyuan@eastchinapharm.com China 1615 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Golden Pharma Co., Limited 		+undefined18958062155 sales@zjgoldpharm.com China 5905 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Standardpharm Co. Ltd. 		58
Career Henan Chemica Co 		58
AFINE CHEMICALS LIMITED 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
sgtlifesciences pvt ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		58
LEAP CHEM CO., LTD. 		58
Golden Pharma Co., Limited 		58

486460-23-5(Sitagliptin N-Boc IMpurity)Related Search:

1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)- Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Impurity 28 Sitagliptin phosphate monohydrate Sitagliptin N-Phoshate IMpurity
Sitagliptin Impurity 27 Sitagliptin Sitagliptin Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
Sitagliptin Impurity 14 (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid 2,4,5-Trifluorobenzaldehyde BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Sitagliptin Impurity 35
Sitagliptin impurity H HCl Sitagliptin Impurity 31 Sitagliptin N-Sulfate

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Sitagliptin N-Boc IMpurity Boc-Sitagliptin N-Boc-Sitagliptin (R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate tert-Butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate Sitagliptin N-Boc tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan- 2-yl)carbamate Sitagliptin Impurity 56 Sitagliptin impurity 10/Sitagliptin N-Boc Impurity/tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate (R)-tert-butyl (4-oxo-4-(3-(trifluoromethyl)- Sitagliptin-3 Sitagliptin Impurity 18 (Sitagliptin N-Boc Impurity) Carbamic acid,[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethylester Sitagliptin N-Boc impurities Carbamic acid, N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester tert-butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-5H,6H,7H,8H-[ 1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorop henyl)butan-2-yl]carbamate Sitagliptin EP Impurity 16 Carbamic acid,[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4... Sitagliptin phosphate impurity 7 Phenol,3-fluoro-8-iodo- Sitagliptin Impurity 03 Sitagliptin Impurity 18 tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5- trifluorophenyl)butan-2-yl)carbamate (R)-[3-Oxo-1-(2,4,5-trifluoro-benzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-propyl]-carbamic acid tert-butyl ester 486460-23-5