DBCO-PEG5-NHS ester
- CAS No.
- 2144395-59-3
- Chemical Name:
- DBCO-PEG5-NHS ester
- Synonyms
- 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber:
- CB44849429
- Molecular Formula:
- C36H43N3O11
- Molecular Weight:
- 693.74
- MDL Number:
- MFCD22380747
- MOL File:
- 2144395-59-3.mol
DBCO-PEG5-NHS ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-24055 | DBCO-PEG5-NHSester 96% | 2144395-59-3 | 25mg | $170 | 2021-12-16 | Buy |
| BroadPharm | BP-24055 | DBCO-PEG5-NHSester 96% | 2144395-59-3 | 100mg | $480 | 2021-12-16 | Buy |
| BroadPharm | BP-24055 | DBCO-PEG5-NHSester 96% | 2144395-59-3 | 500mg | $1650 | 2021-12-16 | Buy |
DBCO-PEG5-NHS ester Chemical Properties,Uses,Production
Description
DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.
Biological Activity
DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| Alkyl/ether
| PEGs
|
DBCO-PEG5-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG5-NHS ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 | lixing@pharmahuici.com | China | 133 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 | lixing@pharmahuici.com | China | 133 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Send Pharmaceutical Technology Co., Ltd. | 021-58088081 Q2816483246 | hailey@shsendpharm.com | China | 3137 | 55 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 4108 | 55 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1246 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
View Lastest Price from DBCO-PEG5-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-20 | DBCO-PEG5-NHS ester
2144395-59-3
|
US $0.00 / mg | 50mg | >99.00% | 250mg | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-PEG5-NHS ester
2144395-59-3
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.