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4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE structure

CAS No.: 757251-39-1

Chemical Name:: 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

Synonyms: RG-M2;Regofenib impurity 4;Regorafenib USP RC A;Regorafenib Impurity 35;Regorafenib Intermediate;Regorafenib EP Impurity A;4-(4-amino-3-fluorophenoxy);AFP-Picolin Methylamide Impurity;4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLIMIDE;4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

CBNumber:: CB51486673

Molecular Formula:: C13H12FN3O2

Molecular Weight:: 261.25

MDL Number:: MFCD09033852

MOL File:: 757251-39-1.mol

MSDS File:: SDS

Last updated:2024-03-28 16:50:06

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4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Properties

Melting point	143 °C
Boiling point	459.8±45.0 °C(Predicted)
Density	1.305
vapor pressure	0Pa at 20℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form	Solid
pka	13.92±0.46(Predicted)
color	Orange to Dark Red to Brown
Water Solubility	190mg/L at 20℃
LogP	1.3 at 25℃

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

HS Code

2933.39.9200

NFPA 704

	0
2		0

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0002093	Regorafenib impurity A European Pharmacopoeia (EP) Reference Standard	757251-39-1	Y0002093	$150	2024-03-01	Buy
TCI Chemical	A2979	4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide >98.0%(HPLC)	757251-39-1	200mg	$37	2024-03-01	Buy
TCI Chemical	A2979	4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide >98.0%(HPLC)	757251-39-1	1g	$110	2024-03-01	Buy
TRC	A609725	4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide	757251-39-1	1g	$315	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0352095	4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 95.00%	757251-39-1	5MG	$502.98	2021-12-16	Buy

Product number	Packaging	Price	Buy
Y0002093	Y0002093	$150	Buy
A2979	200mg	$37	Buy
A2979	1g	$110	Buy
A609725	1g	$315	Buy
HCH0352095	5MG	$502.98	Buy

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Chemical Properties,Uses,Production

Chemical Properties

4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide has the appearance of a white to yellow powder or crystals, which is stable and non-reactive under normal conditions of use, storage and transport.

Uses

4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.

Definition

ChEBI: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is an aromatic ether.

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE synthesis

Synthesis of 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE from 4-bromo-N-methylpicolinamide and 4-Amino-3-fluorophenol

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Preparation Products And Raw materials

Raw materials

4-bromo-N-methylpicolinamide 4-Chloro-N-methylpicolinamide

Preparation Products

Regorafenib

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Suppliers

Global( 249)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Standardpharm Co. Ltd.	58
Shanghai Longyu Biotechnology Co., Ltd.	58

View Lastest Price from 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-03-12	4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 757251-39-1	US $0.00 / kg	1kg	98.0%min	100kg	LY Global chemicals co.,ltd .
2022-08-13	4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide 757251-39-1	US $0.00-0.00 / G	1G	98%min	50kgs/month	Shanghai Rlavie Technology Co ltd
2022-06-24	4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamine 757251-39-1	US $0.00 / g	10g	98%	10tons	Yangzhou Qinyuan Pharmatech Co.,ltd

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE
757251-39-1
US $0.00 / kg
98.0%min
LY Global chemicals co.,ltd .

4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
757251-39-1
US $0.00-0.00 / G
98%min
Shanghai Rlavie Technology Co ltd

4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamine
757251-39-1
US $0.00 / g
98%
Yangzhou Qinyuan Pharmatech Co.,ltd

757251-39-1(4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE)Related Search:

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1of4

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 2-Pyridinecarboxamide,4-(4-amino-3-fluorophenoxy)-N-methyl- 4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYL-2-PYRIDINECARBOXAMIDE 4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide EINECS 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLIMIDE Regorafenib Intermediate 4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamine 4-(4-amino-3-fluorophenoxy) 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamid Regorafenib Impurity 35 Regofenib impurity 4 AFP-Picolin Methylamide Impurity Regorafenib USP RC A Regorafenib EP Impurity A AFP-Picolin Methylamide ImpurityQ: What is AFP-Picolin Methylamide Impurity Q: What is the CAS Number of AFP-Picolin Methylamide Impurity Q: What is the storage condition of AFP-Picolin Methylamide Impurity Q: What are the applications of AFP-Picolin Methylamide Impurity RG-M2 Regorafenib EP Impurity A (Regorafenib USP Related Compound A) 4- (4-Amino-3-fluorophenoxy) - N-methyl-2-pyridylformamide 757251-39-1 797251-39-1 Regorafenib