(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester

(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester structure

CAS No.: 60092-32-2

Chemical Name:: (Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester

Synonyms: Lolidine;(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester;Carbamic acid, (hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methyl-, 1-(acetylamino)-7-chlorohexahydro-1H-pyrrolizin-2-yl ester (9CI)

CBNumber:: CB52329223

Molecular Formula:: C18H27ClN4O4

Molecular Weight:: 398.88

MDL Number:

MOL File:: 60092-32-2.mol

Request For Quotation

(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester Properties

Boiling point	594.3±50.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
pka	14.37±0.60(Predicted)

(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester Chemical Properties,Uses,Production

Description

Russian workers have recently re-examined the alkaloidal extract of the seeds of Lotium cuneatum and shown that, in addition to a number of simple pyrrolizidine bases, it also contains this novel dimeric alkaloid. Lolidine is one of the few bases found in this plant which contains chlorine in the molecule. The base may be separated from the total alkaloids on a silica gel column from Et20 solution. Treatment with either Ac20 or AcCl fails to give the acetyl derivative confirming that the fourth oxygen atom is present in the form of an ether bridge.

References

Batirov, Malikov, Yunusov, Khim. Prir. Soedin., 12,63 (1976)

(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester Preparation Products And Raw materials

Raw materials

Preparation Products

(Hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methylcarbamic acid [6-acetylamino-4-chloro-1-azabicyclo[3.3.0]octan-7-yl] ester Lolidine Carbamic acid, (hexahydro-2,4-methano-4H-furo[3,2-b]pyrrol-3-yl)methyl-, 1-(acetylamino)-7-chlorohexahydro-1H-pyrrolizin-2-yl ester (9CI) 60092-32-2