BAY 80-6946 (Copanlisib)
- CAS No.
- 1032568-63-0
- Chemical Name:
- BAY 80-6946 (Copanlisib)
- Synonyms
- Copanlisib;BAY80-6946;CS-2321;Aliqopa);Copanlisib base;Copanlisib free base;Copanlisib(BAY80-6946);BAY 80-6946 (BAY80-6946;BAY 80-6946 (Copanlisib);BAY 80-6946 (Copanlisib) USP/EP/BP
- CBNumber:
- CB52616024
- Molecular Formula:
- C23H28N8O4
- Molecular Weight:
- 480.52
- MDL Number:
- MFCD18633201
- MOL File:
- 1032568-63-0.mol
- MSDS File:
- SDS
| Density | 1.51 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 8.42±0.20(Predicted) |
| FDA UNII | WI6V529FZ9 |
| ATC code | L01EM02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
BAY 80-6946 (Copanlisib) price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20354 | Copanlisib ≥98% | 1032568-63-0 | 5mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 20354 | Copanlisib ≥98% | 1032568-63-0 | 1mg | $72 | 2023-06-20 | Buy |
| Cayman Chemical | 20354 | Copanlisib ≥98% | 1032568-63-0 | 10mg | $91 | 2024-03-01 | Buy |
| TRC | B119060 | BAY80-6946 | 1032568-63-0 | 10mg | $395 | 2021-12-16 | Buy |
| ChemScene | CS-0741 | Copanlisib 98.91% | 1032568-63-0 | 100mg | $450 | 2021-12-16 | Buy |
BAY 80-6946 (Copanlisib) Chemical Properties,Uses,Production
Binding Mode
As shown in the co-crystal structure of
copanlisib bound to PI3Kγ, the inhibitor binds with
only one critical hydrogen bond to the amide NH of
Val882 in the adenine pocket, employing the
imidazoline N1 nitrogen (Figs. 1 and 2). In addition,
the C5 aminopyrimidine group fills the affinity pocket,
forming hydrogen bonds with two carboxylic
residues of Asp836 and Asp841 through the amino
group. Finally, the solvent exposed morpholine lies
over Trp812, presumably providing additional
attractive molecular contacts.
Uses
BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models.
Definition
ChEBI: Copanlisib is an imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of morpholines, an aromatic ether, a diether, a tertiary amino compound, a secondary carboxamide, a pyrimidinecarboxamide, an aminopyrimidine and an imidazoquinazoline.
brand name
Aliqopa
General Description
Class: lipid kinase; Treatment: FL (IV infusion); Other name: BAY 80-6946; Elimination half-life = 52 h (IV); Protein binding = 84.2%
Pharmacokinetics
Copanlisib has poor oral bioavailability due to low permeability and poor solubility, and therefore, it is not suitable for an oral medication. Consequently, it was developed as an IV drug. IV infusion of copanlisib resulted in rapid distribution throughout the body and a prolonged elimination half-life (52 h).
target
pan-PI3K
Metabolism
Copanlisib was the predominant component in
human plasma, accounting for 84% of total
radioactivity AUC, and the morpholinone metabolite
6 was the only circulating metabolite (about 5%).
BAY 80-6946 (Copanlisib) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27690 | 58 |
View Lastest Price from BAY 80-6946 (Copanlisib) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | BAY 80-6946 (Copanlisib)
1032568-63-0
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- BAY 80-6946 (Copanlisib)
1032568-63-0
- US $2.00 / kg
- 99%
- Career Henan Chemical Co