MOXISYLYTE
- CAS No.
- 54-32-0
- Chemical Name:
- MOXISYLYTE
- Synonyms
- sympal;opilon;Vasoklin;arlytene;moxilite;moxisylyt;moxisylyte;timoxamina;thymoxamine;THYMOXAMINE HCL
- CBNumber:
- CB5506264
- Molecular Formula:
- C16H25NO3
- Molecular Weight:
- 279.37
- MDL Number:
- MFCD00868265
- MOL File:
- 54-32-0.mol
| storage temp. | 2-8°C |
|---|---|
| FDA UNII | PW8QYA7KI0 |
| ATC code | C04AX10,G04BE06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MOXISYLYTE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0008715 | MOXISYLYTE 95.00% | 54-32-0 | 5MG | $501.04 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008715 | MOXISYLYTE 95.00% | 54-32-0 | 1G | $1124.55 | 2021-12-16 | Buy |
| Crysdot | CD12062995 | 4-(2-(Dimethylamino)ethoxy)-5-isopropyl-2-methylphenylacetate 95+% | 54-32-0 | 1g | $608 | 2021-12-16 | Buy |
MOXISYLYTE Chemical Properties,Uses,Production
Originator
Carlytene,Dedieu,France,1962
Uses
alpha-adrenergic blocker
Definition
ChEBI: Acetic acid [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] ester is a monoterpenoid.
Manufacturing Process
A hydrochloric acid solution of 100 g of thymol in alcohol is reacted with 72 g
of sodium nitrite, the nitrosothymol (Organic Syntheses 6, New York, 1926, p.
92) thus obtained is introduced into ammonia, and is reduced by the
introduction of hydrogen sulfide to 4-aminothymol (Organic Syntheses Coll.
Vol. 1, New York, 1932, p. 458). 133.3 g of this 4-aminothymol are mixed
with 67 g of sodium acetate, 107 g of glacial acetic acid and 80 g of acetic
acid anhydride to form 4-acetaminothymol (Plancher, Gazzetta Chimica
Italiana 25, II, p. 388). 156 parts by weight of this last formed substance
dissolved in 600 cc of alcohol are added to a solution of 17.6 parts by weight
of sodium in 600cc of alcohol, the mixture being boiled under reflux for some
time with 82 g of dimethylaminoethyl chloride. The reaction product is treated
with water, and neutralized with hydrochloric acid using acid Congo reagent
indicator, and the alcohol is distilled off in vacuo. The base liberated by alkali
is dissolved in ether. By evaporating the ether solution the dimethylaminoethyl
ether of the 4-acetaminothymol is obtained as a brownish-yellow oil. After
some time this oil solidifies in a crystalline state.
100 g of this base are dissolved in a mixture of 300 cc of concentrated
hydrochloric acid (density 1.19) and 400 cc of water, and the solution is boiled
for one hour under a reflux condenser. Thereupon it is made alkaline,
extracted with ether, and the ether is distilled off. 23.6 g of the 4-
aminothymoxyethyldimethylamine thus obtained are diazotized in the
presence of sulfuric acid at a temperature not exceeding 0°C using a solution
of 7.2 g of sodium nitrite in 70 cc of water, and the diazo compound is heated
to boiling point after the addition of 1 g of copper sulfate, until no further gas
is evolved. It is then made alkaline, and carbon dioxide is introduced. The
base is precipitated first in an oily state, and soon becomes crystalline. The 4-
oxythymoxyethyldimethylamine forms a neutral hydrochloride which is readily
soluble in water, and has a melting point of 174°C to 175.5°C.
36.8 g of 4-oxythymoxyethyldimethylamine are boiled for one hour on a water
bath with 160 cc of acetic anhydride and 17.5 cc of pyridine. After this period,
the solution is diluted with water, made alkaline, and the base is extracted
with ether and the ether distilled off. With acids, the base obtained forms
crystalline salts which are readily soluble in water. The hydrochloride melts
between 208°C and 210°C.
Therapeutic Function
Vasodilator
World Health Organization (WHO)
Moxisylyte was introduced in the late 1980s. It belongs to the group of a-adrenergic blocking agents. In France it is indicated for the treatment of manifestations of benign prostatic hypertrophy. It is also marketed in the UK at lower dosages for the treatment of peripheral vascular disorders (Raynaud's disease).
MOXISYLYTE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 | sales@sunlidabio.com | China | 3750 | 55 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Raw material medicin reagent co.,Ltd | sales@njromanme.com | China | 4534 | 58 | |
| Aikon International Limited | 025-58851090 13611564524 | lwan@aikonchem.com | China | 15952 | 58 |
| Wuhan Yanzhe Technology Co., Ltd | 15527250409 | wenhaotian12@163.com | China | 4576 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10011 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 40041 | 58 |
View Lastest Price from MOXISYLYTE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-28 | MOXISYLYTE USP/EP/BP
54-32-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- MOXISYLYTE USP/EP/BP
54-32-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited