ChemicalBook >> CAS DataBase List >>Manidipine hydrochloride
Manidipine hydrochloride
- CAS No.
- 89226-75-5
- Chemical Name:
- Manidipine hydrochloride
- Synonyms
- Calslot;CV 4093;CV-4093(2HCl);Manidipine DiHCl;cv-4093dihydrochlorde;Manidipine DihydrochL;Hydrochloric Manidipine;franidipinehydrochloride;MANIDIPINE HYDROCHLORIDE;Manidipine Dihydrochlorid
- CBNumber:
- CB5715288
- Molecular Formula:
- C35H40Cl2N4O6
- Molecular Weight:
- 683.62
- MDL Number:
- MFCD00896434
- MOL File:
- 89226-75-5.mol
Last updated:2023-06-08 17:06:35
| Melting point | 157-163°; mp 174-180°; mp 167-170° |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| color | White |
| Water Solubility | Soluble in DMSO. Slightly soluble in water and ethanol /n |
| Merck | 14,5743 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 89226-75-5(CAS DataBase Reference) |
| FDA UNII | ZL507UZ6QL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Symbol(GHS) | GHS06 |
| Signal word | Danger |
| Signal word | Danger |
| Hazard statements | H301-H336 |
| Hazard statements | H301-H336 |
| Precautionary statements | P261-P264-P301+P310+P330-P304+P340+P312-P403+P233-P501 |
| Precautionary statements | P261-P264-P301+P310+P330-P304+P340+P312-P403+P233-P501 |
| RIDADR | UN 2811 6.1/PG III |
| RTECS | US7975300 |
| HS Code | 2933.59.8000 |
| HazardClass | 6.1 |
| PackingGroup | III |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba) |
Manidipine hydrochloride price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2425 | Manidipine hydrochloride ≥98% (HPLC) | 89226-75-5 | 5mg | $53.28 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2425 | Manidipine hydrochloride ≥98% (HPLC) | 89226-75-5 | 25mg | $359 | 2024-03-01 | Buy |
| TCI Chemical | M2225 | Manidipine Dihydrochloride >98.0%(HPLC)(T) | 89226-75-5 | 1g | $168 | 2024-03-01 | Buy |
| TCI Chemical | M2225 | Manidipine Dihydrochloride >98.0%(HPLC)(T) | 89226-75-5 | 5g | $577 | 2023-06-20 | Buy |
| Alfa Aesar | J60496 | Manidipine dihydrochloride | 89226-75-5 | 25mg | $99.65 | 2024-03-01 | Buy |
Manidipine hydrochloride Chemical Properties,Uses,Production
Description
Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4
Uses
aldosterone antagonist
Uses
Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.
Definition
ChEBI: Manidipine dihydrochloride is a diarylmethane.
References
Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130
Manidipine hydrochloride Preparation Products And Raw materials
Global( 277)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 288 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
View Lastest Price from Manidipine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-15 | Manidipine hydrochloride
89226-75-5
|
US $1.00 / mg | 1mg | 0.99 | 5ton/month | ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD | |
 |
2023-08-16 | Manidipine hydrochloride
89226-75-5
|
US $450.00 / KG | 1KG | >99% | 50000kg/Month | Weijer International Trade (Hebei) Co., Ltd | |
 |
2022-08-13 | Manidipine hydrochloride
89226-75-5
|
US $100.00 / kg | 1kg | 99% | 5000 Ton | Hebei Duling International Trade Co. LTD |
-
- Manidipine hydrochloride
89226-75-5
- US $1.00 / mg
- 0.99
- ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
-
- Manidipine hydrochloride
89226-75-5
- US $450.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd
-
- Manidipine hydrochloride
89226-75-5
- US $100.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
89226-75-5(Manidipine hydrochloride)Related Search:
4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride
cv-4093dihydrochlorde
franidipinehydrochloride
MANIDIPINE DIHYDROCHLORIDE
MANIDIPINE HYDROCHLORIDE
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
Calslot
3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[4-(diphenylMethyl)-1-piperazinyl]ethyl] 5-Methyl ester, hydrochloride(1:2)
CV-4093(2HCl)
Manidipine dihydrochloride (CV-4093)
CV 4093
Hydrochloric Manidipine
Manidipine DiHCl
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)
Manidipine dihydrochloride, >=99%
Manidipine Dihydrochlorid
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyr
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride
Manidipine Hydrochloride RS
ManidipineDihydrochloride>
Manidipine DihydrochL
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbo
Manidipine hydrochloride USP/EP/BP
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
Manidipine dihydrochloride salt
3-[2-(4-Benzhydryl-1-piperazinyl)ethyl] 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Dihydrochloride
Manidipine Dihydrochloride, ≥ 98.0%
89226-75-5
82926-75-5
C35H38N4O6HCl
C35H40Cl2N4O6
C35H38N4O62HCl
Antihypertensive
API