Prazosin hydrochloride

Prazosin hydrochloride Properties

Melting point	277 - 280 °C
storage temp.	2-8°C
solubility	H₂O: 1 mg/mL, clear, colorless
form	solid
color	white
Water Solubility	Soluble in dimethyl sulfoxide, ethanol, water, methanol.
Merck	14,7717
BRN	4303561
InChIKey	WFXFYZULCQKPIP-UHFFFAOYSA-N
CAS DataBase Reference	19237-84-4(CAS DataBase Reference)
FDA UNII	X0Z7454B90

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H302-H315-H319-H335-H361

Precautionary statements

P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313

Hazard Codes

Xn

Risk Statements

22-36/37/38-62

Safety Statements

28-36

RIDADR

3249

WGK Germany

3

RTECS

VA1350000

F

10

HazardClass

6.1(b)

PackingGroup

III

HS Code

2934990002

Toxicity

dog,LD50,oral,> 700mg/kg (700mg/kg),GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSKIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING,Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979.

NFPA 704

	0
2		0

Prazosin hydrochloride price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3099	Prazosin Hydrochloride pharmaceutical secondary standard, certified reference material	19237-84-4	500MG	$229	2024-03-01	Buy
Sigma-Aldrich	P7791	Prazosin hydrochloride ≥99.0% (HPLC)	19237-84-4	1g	$906	2024-03-01	Buy
Sigma-Aldrich	1554705	Prazosin hydrochloride United States Pharmacopeia (USP) Reference Standard	19237-84-4	350mg	$436	2024-03-01	Buy
TCI Chemical	P0938	Prazosin Hydrochloride >98.0%(T)	19237-84-4	100mg	$66	2024-03-01	Buy
TCI Chemical	P0938	Prazosin Hydrochloride >98.0%(T)	19237-84-4	1g	$244	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR3099	500MG	$229	Buy
P7791	1g	$906	Buy
1554705	350mg	$436	Buy
P0938	100mg	$66	Buy
P0938	1g	$244	Buy

Prazosin hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White to Yellow Powder

Originator

Hypovase, Pfizer, UK,1974

Uses

Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.

Uses

Prazosin hydrochloride has been used:

to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
as an α1-adrenoceptor blocker,administered intragastrically in rats
as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Manufacturing Process

Preparation of 2-Chloro-4-Amino-6,7-Dimethoxyquinazoline: To 800 ml of a solution of anhydrous ammonia in tetrahydrofuran at room temperature is added 30 g of 2,4-dichloro-6,7-dimethoxyquinazoline [F.H.S. Curd et al., J. Chem. Soc., p 1759 (1948)]. The mixture is stirred for 44 hours. The precipitate (29 g, MP 267° to 268°C) is filtered and recrystallized from methanol to yield 19 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline, MP 302°C (dec.).
Preparation of 2-(1-Piperazinyl)-4-Amino-6,7-Dimethoxyquinazoline: To 5 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline, is added 20 g of a 25% solution of piperazine in ethanol. The mixture is heated at 160°C for 16 hours in a pressure bottle. The solvent is then evaporated and the residue is recrystallized from methanol/water.
Preparation of 2[4-(2-Furoyl)-Piperazinyl]-4-Amino-6,7-Dimethoxyquinazoline: To 0.10 mol 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline in 300 ml methanol is added with vigorous stirring, 0.10 mol 2-furoyl chloride. After addition is complete, the mixture is stirred for 3 hours at room temperature. The solids are filtered to give the desired product, MP 278° to 280°C.

brand name

Minipress (Pfizer).

Therapeutic Function

Antihypertensive

General Description

The antihypertensive effectsof prazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride(Minipress), are caused by peripheral vasodilation as a resultof its blockade of 1-adrenergic receptors. In ligand-bindingstudies, prazosin hydrochloride has 5,000-fold greater affinityfor α1-receptors than for some α2-adrenergic receptors.

Biological Activity

α 1 and α 2B -adrenoceptor antagonist. Also a potent antagonist at the melatonin MT 3 receptor (K i = 10.2 nM). Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .

Biochem/physiol Actions

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Clinical Use

Prazosin hydrochloride is readily absorbed, and plasmaconcentrations reach a peak about 3 hours after administration.Plasma half-life is between 2 and 3 hours. Prazosin hydrochlorideis highly bound to plasma protein; it does notcause adverse reactions, however, with drugs that might bedisplaced from their protein-binding sites (e.g., cardiac glycosides).It may cause severe orthostatic hypertension becauseof its -adrenergic blocking action, which preventsthe reflex venous constriction that is activated when an individualsits up from a prone position.

storage

Room temperature

Purification Methods

The salt is recrystallised by dissolving it in hot MeOH, adding a small volume of MeOH/HCl (dry MeOH saturated with dry HCl gas) followed by dry Et2O until crystallisation is complete. Dry it in vacuo over solid KOH till the odour of HCl is absent. It has been recrystallised from hot H2O, the crystals are washed with H2O, and the H2O is removed azeotropically with CH2Cl2, and dried in a vacuum. [NMR and IR: Honkanen et al. J Heterocycl Chem 17 797 1980, cf Armarego & Reece Aust J Chem 34 1561 1981.] It is an antihypertensive drug and is an 1-adrenergic antagonist [Brosman et al. Proc Natl Acad Sci USA 82 5915 1985].

Prazosin hydrochloride Preparation Products And Raw materials

Raw materials

2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE 2-Furoyl chloride Ammonia 2-Chloro-4-amino-6,7-dimethoxyquinazoline Piperazine

Preparation Products

Prazosin hydrochloride Suppliers

Global( 323)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58

View Lastest Price from Prazosin hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-02-01	Prazosin hydrochloride 19237-84-4	US $500.00 / kg	1kg	99%	5000 tons	Hebei Duling International Trade Co. LTD
2021-11-04	Prazosin hydrochloride 19237-84-4	US $10.00 / Kg/Bag	1Kg/Bag	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd
2021-11-02	Prazosin hydrochloride 19237-84-4	US $1269.00 / Kg/Bag	100g	98%+	500kg	Baoji Guokang Healthchem co.,ltd

Prazosin hydrochloride
19237-84-4
US $500.00 / kg
99%
Hebei Duling International Trade Co. LTD

Prazosin hydrochloride
19237-84-4
US $10.00 / Kg/Bag
99%
Hebei Zhanyao Biotechnology Co. Ltd

Prazosin hydrochloride
19237-84-4
US $1269.00 / Kg/Bag
98%+
Baoji Guokang Healthchem co.,ltd

Prazosin hydrochloride Spectrum

Prazosin hydrochloride(19237-84-4)¹HNMR

19237-84-4(Prazosin hydrochloride )Related Search:

Topotecan hydrochloride 1-AdaMantanethylaMine Tris(hydroxymethyl)aminomethane Prazosin Glycine

Piperazine Diphenyldimethoxysilane Dimethoxymethane 6-Aminocaproic acid Dimethyldimethoxysilane

Dimethylamine hydrochloride 3-Aminophenol Cetirizine dihydrochloride ALTRENOGEST 1,1-Dimethoxyethane

Diphenhydramine Hydrochloride Terazosin impurity 2-Piperazine-4-amino-6,7-dimethoxyquinazoline Prazosin Hcl

1of4

4-Amino-2-pyroyl-6,7-dimetoxypiperazin-1-yl-chynazolina hydrochloride Furazosin hydrochloride, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride [4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone hydrochloride Prazosin hydrochloride,1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride Prazosin Hydrochloride (500 mg) Prazosin hydrochlori 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazinehydr [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanylMethanone Hydrochloride 1-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-4-(2-furanylcarbonxyl) piperazine Hydrochloride Adversuten Adverszuten Alpress LP (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone hydrochloride Prazosin Hydrochloride (350 mg) 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride PRAZOSIN HYDROCHLORIDE USP PRAZOSIN HYDROCHLORIDE PERIPHERAL A1 ADR ENER Prazosin HCl USP PrazosinHclC19H21N504.HC1 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazinemonohydrochlo 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-piperazinmonohydro 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazolinehydrochloride 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-quinazolinhydrochlori cp-12299-1 deprazolin hypovase FURAZOSIN HYDROCHLORIDE PRAZOSIN HYDROCHLORIDE Alpress LP, Eurex, Hypovase, Minipress, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonxyl)piperazine, Hydrochloride Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-, monohydrochloride 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2-furoyl)piperazinmonohydrochlorid hypovasole peripress pratsiol prazosinclorhidrato sinetens 1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(2-FURANYLCARBONYL)PIPERAZINE HYDROCHLORIDE 1-(3-AMINO-6,7-DIMETHOXY-2-QUINAZOLINY)-4-(2-FURANYLCARBONYL)PIPERAZINE Terazosin Impurity14 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(furan-2-ylcarbonyl) piperazine hydrochloride Terazosin-010-HCl Terazosin Impurity 11(Terazosin EP Impurity K) [4-(4-amino-6,7-dimethoxy-2-quinazolin-3-iumyl)-1-piperazinyl]-(2-furanyl)methanone Methanone,[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-,hydrochloride (1:1) Prazosin hydrochloride CRS PrazosinHydrochloride> Prazosin HCl (Furazosin HCl, Terazosin EP Impurity K HCl) Prazosin Hydrochloride RS Prazosin hydrochloride salt Vasoflex Prazosin hydrochloride Solution in Methanol, 100μg/mL Prazosin HCl (Furazosin HCl) Prazosin hydrochloride USP/EP/BP prazosin HCLr Prazosin Hydrochloride (1.0 mg/mL in Methanol) Terazosin EP Impurity K (Prazosin) tianfu-chem_ Prazosin hydrochloride 19237-84-4 Prazosin Hydrochloride (1554705)