20,22-dihydroxycholesterol
- CAS No.
- 596-94-1
- Chemical Name:
- 20,22-dihydroxycholesterol
- Synonyms
- Oxy-16;Oxy-16, Oxysterol;20,22-dihydroxycholesterol;ISBSSBGEYIBVTO-RCXKVKFCSA-N;(3β,22R)-Dihydroxy Cholesterol;(3β,22R)-Dihydroxy Cholesterol;20α,22(R)-Dihydroxycholesterol;(20R,22R)-Dihydroxycholesterol;(22R)-5-Cholesten-3β,20α,22-triol;(22R)-Cholest-5-ene-3β,20,22-triol
- CBNumber:
- CB61372988
- Molecular Formula:
- C27H46O3
- Molecular Weight:
- 418.65
- MDL Number:
- MFCD00870394
- MOL File:
- 596-94-1.mol
| Melting point | 183 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 553.5±25.0 °C(Predicted) |
| Density | 1.08±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤10mg/ml in ethanol;1.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 14.42±0.29(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
20,22-dihydroxycholesterol price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9000395 | Oxy-16 ≥95% | 596-94-1 | 1mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 9000395 | Oxy-16 ≥95% | 596-94-1 | 5mg | $537 | 2024-03-01 | Buy |
| Cayman Chemical | 9000395 | Oxy-16 ≥95% | 596-94-1 | 10mg | $952 | 2024-03-01 | Buy |
| TRC | D452465 | (3β,22R)-DihydroxyCholesterol | 596-94-1 | 2.5mg | $165 | 2021-12-16 | Buy |
| AK Scientific | 1673AH | Cholest-5-ene-3beta,20,22R-triol | 596-94-1 | 1mg | $232 | 2021-12-16 | Buy |
20,22-dihydroxycholesterol Chemical Properties,Uses,Production
Description
Naturally occurring oxysterols are products of cholesterol oxidation that can stimulate the hedgehog (Hh) signaling pathway in target cells associated with cardiovascular disease and with bone formation. Depending on the target cell, activation of Hh signaling can modulate inflammatory responses to additional atherogenic factors such as lesion-
Uses
A metabolite of Cholesterol (C432501). Cholesterol is metabolized to Pregnenolone by way of 22R-hydroxycholesterol and 20R,22R-dihydroxycholesterol by P 450scc.
Definition
ChEBI: An oxysterol that is cholesterol substituted by hydroxy groups at positions 20 and 22 (the 20R,22R-stereoisomer).
in vitro
oxysterols have been shown to be associated with immunosuppression, apoptosis, atherosclerosis, inflammation, and cholesterol turnover. other studies aslo indicated that oxysterols were hedgehog (hh) signaling pathway activators and had potent osteoinductive properties. oxy-16, an oxysterol, was identified as a cell permeable oxygenated derivative of cholesterol that might be the end product or intermediate of the cholesterol excretion pathways. oxy-16 is currently used as a transport form for cholesterol across the blood brain barrier and membranes. the osteogenic differentiation caused by oxy-16 was cinsidered to be mediated via a wnt signaling-related, dkk-1-inhibitable mechanism [1].
References
[1] amantea, c. m.,kim, w.k.,meliton, v., et al. oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by dkk-1 inhibitable and pi3-kinase mediated signaling. journal of cellular biochemistry 105(2), 424-436 (2008).
20,22-dihydroxycholesterol Preparation Products And Raw materials
Raw materials
Preparation Products
20,22-dihydroxycholesterol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29803 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |