Aurora A Inhibitor I
- CAS No.
- 1158838-45-9
- Chemical Name:
- Aurora A Inhibitor I
- Synonyms
- Aurora A-IN-10;Aurora A Inhibitor I;TC-S 7010 Aurora A Inhibitor;Aurora A Inhibitor I USP/EP/BP;TC-S 7010 (Aurora A Inhibitor I);Aurora A Inhibitor I (TC-S 7010);Aurora-A Inhibitor I >=98% (HPLC);N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)-phenyl)amino)-5-fluoropyri;N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)-phenyl)amino)-5-fluoropyrimid;N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
- CBNumber:
- CB62506281
- Molecular Formula:
- C31H31ClFN7O2
- Molecular Weight:
- 588.07
- MDL Number:
- MFCD16495816
- MOL File:
- 1158838-45-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P305+P351+P338-P280 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Aurora A Inhibitor I price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0882 | Aurora-A Inhibitor I ≥98% (HPLC) | 1158838-45-9 | 5mg | $165 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0882 | Aurora-A Inhibitor I ≥98% (HPLC) | 1158838-45-9 | 25mg | $657 | 2024-03-01 | Buy |
| Cayman Chemical | 21600 | Aurora A Inhibitor I ≥98% | 1158838-45-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21600 | Aurora A Inhibitor I ≥98% | 1158838-45-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 21600 | Aurora A Inhibitor I ≥98% | 1158838-45-9 | 10mg | $243 | 2024-03-01 | Buy |
Aurora A Inhibitor I Chemical Properties,Uses,Production
Uses
TC-S 7010 is a selective Aurora A inhibitor.
Definition
ChEBI: N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]anilino]-5-fluoro-4-pyrimidinyl]amino]benzamide is a member of benzamides.
Biological Activity
aurora a inhibitor i is a novel, potent, and selective inhibitor of aurora a .aurora kinases are reported to be required for mitosis and to complete cell division. because of this, aurora kinase inhibitors have been investigated extensively as potential anticancer therapeutic agents. the two major aurora kinases (aurora a and aurora b) are closely related in kinase domain sequence (71% identical).
in vitro
aurora a inhibitor i was tested against wild-type kinase and two mutants (aurora a (t217e) and aurora b (e161t)). the inhibitory potencies of aurora a inhibitor i was strongly affected by the single amino acid substitutions. for either aurora kinase, the presence of threonine allowed potent inhibition, while for glutamic acid variants, there was a approximately 100-fold shift in ic50, which supported the “gating” role for this residue. the aurora b binding pocket was enlarged by the e161t mutation, while the pocket in aurora a was closed by the t217e mutation. aurora a inhibitor i was exceptionally selective aurora a inhibitors, as shown by no inhibition on aurora b or cdks was observed in cellular assays [1].
IC 50
3.4 nm.
storage
Store at +4°C
References
[1] aliagas-martin i,burdick d,corson l,dotson j,drummond j,fields c,huang ow,hunsaker t,kleinheinz t,krueger e,liang j,moffat j,phillips g,pulk r,rawson te,ultsch m,walker l,wiesmann c,zhang b,zhu by,cochran ag. a class of 2,4-bisanilinopyrimidine aurora a inhibitors with unusually high selectivity against aurora b. j med chem.2009 may 28;52(10):3300-7.
Aurora A Inhibitor I Preparation Products And Raw materials
Raw materials
Preparation Products
Aurora A Inhibitor I Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |