FG 2216
- CAS No.
- 223387-75-5
- Chemical Name:
- FG 2216
- Synonyms
- BIQ;IOX-3;YM 311;FG2216;FG-2216;FG 2216;CS-1687;FG-2216(IOX3;FG-2216 - YM 311;FG2216;FG-2216;FG 2216
- CBNumber:
- CB62666905
- Molecular Formula:
- C12H9ClN2O4
- Molecular Weight:
- 280.66
- MDL Number:
- MOL File:
- 223387-75-5.mol
- MSDS File:
- SDS
| Boiling point | 670.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.571±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic |
| form | powder |
| pka | 3.20±0.10(Predicted) |
| color | white to beige |
| FDA UNII | RU921DS4Z5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
FG 2216 price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1811 | BIQ ≥98% (HPLC) | 223387-75-5 | 5mg | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1811 | BIQ ≥98% (HPLC) | 223387-75-5 | 25mg | $639 | 2024-03-01 | Buy |
| Cayman Chemical | 18382 | FG-2216 ≥98% | 223387-75-5 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18382 | FG-2216 ≥98% | 223387-75-5 | 5mg | $140 | 2024-03-01 | Buy |
| Cayman Chemical | 18382 | FG-2216 ≥98% | 223387-75-5 | 10mg | $257 | 2024-03-01 | Buy |
FG 2216 Chemical Properties,Uses,Production
Description
FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.
Uses
FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.
Biochem/physiol Actions
BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.
References
1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.
FG 2216 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
