ChemicalBook >> CAS DataBase List >>(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid structure

CAS No.: 1012341-50-2

Chemical Name:: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Synonyms: (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid;(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84;AHU;sacubitril intermediate;AHU08;LCZ696-24;4S)-5-([1;LCZ696 INT;LCZ696S-01;LCA696 inter

CBNumber:: CB62723688

Molecular Formula:: C23H29NO4

Molecular Weight:: 383.48

MDL Number:: MFCD27955981

MOL File:: 1012341-50-2.mol

Last updated:2024-02-06 18:17:50

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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Properties

Melting point	145-147°C
Boiling point	582.6±50.0 °C(Predicted)
Density	1.115±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	4?+-.0.23(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1/C23H29NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,16,20H,14-15H2,1-4H3,(H,24,27)(H,25,26)/t16-,20+/s3
InChIKey	YNELJETWNMPEEH-OXDNQSQGNA-N
SMILES	C(O)(=O)[C@H](C)C[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 \|&1:3,6,r\|
FDA UNII	FJ7AWX8DMF

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B412965	(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoicAcid	1012341-50-2	5g	$340	2021-12-16	Buy
Matrix Scientific	153215	(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 95%	1012341-50-2	5g	$115	2021-12-16	Buy
Chemenu	CM101918	(2R,4S)-5-([1,1''-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoicacid 95%	1012341-50-2	5g	$281	2021-12-16	Buy
Crysdot	CD21019730	(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoicacid 95+%	1012341-50-2	5g	$297	2021-12-16	Buy
Chemenu	CM101918	(2R,4S)-5-([1,1''-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoicacid 95%	1012341-50-2	10g	$468	2021-12-16	Buy

Product number	Packaging	Price	Buy
B412965	5g	$340	Buy
153215	5g	$115	Buy
CM101918	5g	$281	Buy
CD21019730	5g	$297	Buy
CM101918	10g	$468	Buy

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Chemical Properties,Uses,Production

Uses

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid is a useful building block in the synthesis of various pharmaceuticals. Could be useful for treating bacterial infectious disease.

Synthesis

Dissolve 2g [Ru] catalyst (diiodo(p-cymene) ruthenium(II) dimer) and 1.3g (R,R)-Me-Duphos in 20mL toluene, and react at 65-70 for one hour , Prepared as a chiral catalyst. Add the toluene solution of the above chiral catalyst into a clean hydrogenation kettle, and sequentially add SM1 (763g), 202g triethylamine, and 16L methanol solvent, and then seal the hydrogenation kettle to replace the nitrogen for three times and then replace the hydrogen for three times (0.4-0.5MPa) The reaction was carried out at 55°C for 12 hours under pressure, and the reaction liquid was taken for liquid phase detection. The conversion rate of reaction SM1 reached 99.99%. The reaction solution is filtered and concentrated, and the pure (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid can be obtained by beating with n-hexane and ethyl acetate (1:1); the yield is 96.1%, and the product is an off-white solid.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid synthesis

Synthesis of (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid from (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Preparation Products And Raw materials

Raw materials

AHU377-BOC double button LCZ699 Impurity 598-11 1-Pyrrolidinecarboxylic acid, 5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxo-, 1,1-dimethylethyl ester, (3R,5S)- (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

Preparation Products

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Suppliers

Global( 400)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changsha Junyu Chemexpress.co., Ltd	+86-13723890100	info@csjyyy.cn	China	134	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	+undefined-0518-86098006 +undefined19851887368	lvan.hui@jsytsw.com	China	80	58
ChemExpress	+86-021-58950125	info@chemexpress.com	China	566	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6011	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	326	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15954	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55

Supplier	Advantage
Changsha Junyu Chemexpress.co., Ltd	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	58
ChemExpress	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Beijing Cooperate Pharmaceutical Co.,Ltd	55

View Lastest Price from (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-06-07	(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2	US $130.00 / kilograms	1kilograms	99%	10	Hebei Dangtong Import and export Co LTD
2024-05-30	(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2	US $0.00-0.00 / kg	0.10000000149011612kg	99	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-03-28	(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 1012341-50-2	US $0.00 / KG	25KG	98%	Inquiry	PNP Biotech Co. Ltd

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
1012341-50-2
US $130.00 / kilograms
99%
Hebei Dangtong Import and export Co LTD

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
1012341-50-2
US $0.00-0.00 / kg
99
Chongqing Zhihe Biopharmaceutical Co., Ltd.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2
US $0.00 / KG
98%
PNP Biotech Co. Ltd

1012341-50-2((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid)Related Search:

N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester LCZ696 InteMediate (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid LCZ Impurity LCZ696

(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

(2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid Valsartan (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid

AHU-377 (heMicalciuM salt) ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester Sacubitril Impurity 72

1of4

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid LCZ696 inter. (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic LCZ696 INT [1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS) (2R,4S)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic acid LCA696 inter (2R,4S)-5-(4-Biphenylyl)-2-methyl-4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)pentanoic acid (2R, 4S) -5- ([1,1'-]-4- based -4- (biphenyl) (TERT butoxycarbonyl) amino) -2- methyl valerate LCZ-696-001-SS LCZ696-24 (2R,4S)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methylpentanoic Acid (2R, 4S) -5- (biphenyl-4-yl) -4-[(tert-butoxycarbonyl) amino] -2-methylvaleric acid LCZ696S-01 AHU08 1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 4S)-5-([1 (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid [DMF No. 031502] (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic aci LCZ-696 Intermediate 40(R,R) 1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)- (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid ISO 9001：2015 REACH LCZ696 intermediates，(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4- ((tert-butoxycarbonyl)amino)-2- methylpentanoic acid Valsartan Impurity 80 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)ami... LCZ696 impurities123 (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acidQ: What is (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the CAS Number of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the storage condition of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What are the applications of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid the intermidiate of AHU-377 Sacubitril-Valsartan Hydrate (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid sacubitril intermediate AHU (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxy LCZ-696 Intermediate 40 Propanoicacid,3-cyano-2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(7S)- 2-PYRIMIDINEMETHANOL,7-HYDROXY (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-meth (αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid (2R,4S)-5-((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Salcubatra calcium impurity 14 SACUBITRIL N-BOC ACID (SAV-2) Entresto intermediate N-3 LCZ696 Intermediate N-3 Sacubitril intermediates (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2R,4S)-5-([1,1'-biphenyl]-4-y1)-4-((tert-butoxycarbonyl) amino)-2-methylpentanoic acid (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2 1 intermediates intermediate LCZ696 032-LCZ696 1012341-50-2