Cyclosporin H
- CAS No.
- 83602-39-5
- Chemical Name:
- Cyclosporin H
- Synonyms
- CS-1741;CS-1030;Sandoz 37-839;CYCLOSPORIN H;CsH cyclosporin;Cyclosporin H, >=95%;Cyclosporin impurity H;Cyclosporine IMpurity-H;Cyclosporine Impurity 8;Cyclosporin H, EvoPure?
- CBNumber:
- CB8279114
- Molecular Formula:
- C62H111N11O12
- Molecular Weight:
- 1202.61
- MDL Number:
- MFCD04039488
- MOL File:
- 83602-39-5.mol
| Melting point | 148-151°C |
|---|---|
| Boiling point | 1293.8±65.0 °C(Predicted) |
| Density | 1.016±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated) |
| pka | 13.32±0.70(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -100 to -115°, c = 0.5 in methanol |
| FDA UNII | FUO6O3NDNH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H350-H360 | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| HS Code | 29420000 | |||||||||
| NFPA 704 |
|
Cyclosporin H price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1575 | Cyclosporin H ≥97% (HPLC) | 83602-39-5 | 1mg | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1575 | Cyclosporin H ≥97% (HPLC) | 83602-39-5 | 5mg | $435 | 2024-03-01 | Buy |
| Cayman Chemical | 17182 | Cyclosporin H ≥95% | 83602-39-5 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 17182 | Cyclosporin H ≥95% | 83602-39-5 | 5mg | $385 | 2024-03-01 | Buy |
| Tocris | 6982 | Cyclosporin H ≥97%(HPLC) | 83602-39-5 | 5 | $295 | 2021-12-16 | Buy |
Cyclosporin H Chemical Properties,Uses,Production
Description
Cyclosporin H is a natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 μM. Unlike cyclosporin A , cyclosporin H does not bind cyclophilin to evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit phorbol ester-mediated effects in mouse skin and block calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
Chemical Properties
White Powder
Uses
Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclopsorin H is the most extensively investigated of the minor cyclosporin analogues and displays a range of activities. It is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.
Uses
Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Uses
An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Biochem/physiol Actions
Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils. Cyclosporin H does not bind cyclophilin or evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit tumor promoting phorbol ester TPA/PMA in mouse skin cells and to inhibit calcium/calmodulin-dependent EF-2 phosphorylation.
storage
+4°C
References
[1]. wenzel-seifert k, seifert r. cyclosporin h is a potent and selective formyl peptide receptor antagonist. comparison with n-t-butoxycarbonyl-l-phenylalanyl-l-leucyl-l-phenylalanyl-l- leucyl-l-phenylalanine and cyclosporins a, b, c, d, and e. j immunol, 1993, 150(10): 4591-4599.
[2]. wenzel-seifert k, grünbaum l, seifert r. differential inhibition of human neutrophil activation by cyclosporins a, d, and h. cyclosporin h is a potent and effective inhibitor of formyl peptide-induced superoxide formation. j immunol, 1991, 147(6): 1940-1946.
[3]. de paulis a, ciccarelli a, de crescenzo g, et al. cyclosporin h is a potent and selective competitive antagonist of human basophil activation by n-formyl-methionyl-leucyl-phenylalanine. j allergy clin immunol, 1996, 98(1): 152-164.
[4]. kitagaki k, nagai h, hayashi s, et al. facilitation of apoptosis by cyclosporins a and h, but not fk506 in mouse bronchial eosinophils. eur j pharmacol, 1997, 337(2-3): 283-289.
Cyclosporin H Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Excellent Biomedical Technology Co.,Ltd. | +86-0755-26050679 +86-15915472436 | sale@ex-biotech.cn | China | 1031 | 58 |
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| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
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| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |