Baclofen-d4
- CAS No.
- 1189938-30-4
- Chemical Name:
- Baclofen-d4
- Synonyms
- [2H4]-Baclofen;(±)-Baclofen-d4 (4-chlorophenyl-d4);(+/-)-BACLOFEN (D4, 98%) 100 UG/ML IN METHANOL;Baclofen D4 HydrochlorideQ: What is Baclofen D4 Hydrochloride Q: What is the CAS Number of Baclofen D4 Hydrochloride Q: What is the storage condition of Baclofen D4 Hydrochloride Q: What are the applications of Baclofen D4 Hydrochloride
- CBNumber:
- CB83586734
- Molecular Formula:
- C10H8D4ClNO2
- Molecular Weight:
- 217.685427112
- MDL Number:
- MOL File:
- 1189938-30-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H334-H317-H360-H335 | |||||||||
| Precautionary statements | P201-P202-P261-P264-P270-P271-P272-P280-P284-P301+P310-P321-P330-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P362+P364-P333+P313-P337+P313-P342+P311-P363-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Baclofen-d4 price More Price(3)
Baclofen-d4 Chemical Properties,Uses,Production
Uses
Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
Biological Activity
(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
References
1.Hill, D.R., and Bowery, N.G.3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brainNature290(5802)(1981) 2.Biscoe, T.J., and Fry, J.P.Some pharmacological studies on the spastic mouseBr. J. Pharmacol. 75(1)23-25(1982) 3.Sakitani, K.The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in ratsJpn. J. Pharmacol.63(3)369-376(1993) 4.Lhuillier, L., Mombereau, C., Cryan, J.F., et al.GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaineNeuropsychopharmacology32(2)388-398(2007) 5.Moore, E.M., and Boehm, S.L., IISite-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J miceBehav. Neurosci.123(3)555-563(2009)
Baclofen-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
Baclofen-d4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SIMSON PHARMA LIMITED | +91-8291074273 | k.das@simsonpharma.com | India | 228 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9911 | 50 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | shanpel@anpel.com.cn | China | 9614 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4984 | 58 |
| Yancheng Tongming Biotechnology Co., Ltd. | 15195160625 | 2863565288@qq.com | China | 5194 | 58 |
View Lastest Price from Baclofen-d4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-05-27 | Baclofen-D4
1189938-30-4
|
US $0.00-0.00 / mg | 1mg | 96% | 50 mg | Simson Pharma limited |
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- Baclofen-D4
1189938-30-4
- US $0.00-0.00 / mg
- 96%
- Simson Pharma limited