pilocarpidine
- CAS No.
- 127-67-3
- Chemical Name:
- pilocarpidine
- Synonyms
- pilocarpidine;Einecs 204-856-8;N-Demethylpilocarpine;2(3H)-Furanone, 3-ethyldihydro-4-(1H-imidazol-4-ylmethyl)-, (3S,4R)-;(3S,4R)-3-Ethyl-4,5-dihydro-4-[(1H-imidazol-5-yl)methyl]furan-2(3H)-one;(3S,4R)-3-Ethyl-4,5-dihydro-4-[(1H-imidazole-5-yl)methyl]-2(3H)-furanone
- CBNumber:
- CB8891406
- Molecular Formula:
- C10H14N2O2
- Molecular Weight:
- 194.23
- MDL Number:
- MOL File:
- 127-67-3.mol
pilocarpidine Chemical Properties,Uses,Production
Description
The leaves of Pilocarpus Jaborandi contain this alkaloid but not those of P. microphyllus. The alkaloid is a viscous oil which decomposes on attempted distillation. It has [α]20D + 81.3° (H20) falling to + 35.2° on the addition of alkali. The salts are well crystallized and include the hydrochloride which has [α]~O + 72° (H20); nitrate, m.p. 137°C; [α]20D + 73.2° (H20); aurichloride, m.p. 125 C and the platinichloride tetrahydrate, m.p. 187°C (dry, dec.). In contrast to the corresponding salts of pilocarpine and isopilocarpine (q.v.) the picrate is a non-crystallizable oil. When heated with alkalies, the salts evolve dimethylamine and on treatment with alcoholic sodium methoxide, the base gives isopilocarpidine, characterized as the nitrate, m.p. 109-111 °C. The latter, on quaternary methylation furnishes isopilocarpine metho-salts, e.g. the methopicrate, m.p. 119-120°C.
Definition
ChEBI: Pilocarpidine is a gamma-lactone.
References
Harnack., Annalen, 238,230 (1887)
Jowett., J. Chem. Soc., 77,474 (1900)
Burtles, Pyman, Roylance., ibid, 127,581 (1925)
Spath, Kunz., Ber., 58,513 (1925)
Preobrashenski et al., ibid, 69, 1837 (1936)
pilocarpidine Preparation Products And Raw materials
Raw materials
Preparation Products
pilocarpidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 14760821013; 14760821013 | 1816280386@qq.com | China | 9036 | 58 |
| Supplier | Advantage |
|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 58 |