codeine phosphate
- CAS No.
- 52-28-8
- Chemical Name:
- codeine phosphate
- Synonyms
- Tricodein;Galcodine;Coducept Phosphate;Codicept Phosphate;CodeinePhosphate[D.D];Codeine phosphate (1:1);Phosphoric acid codeine;Codeine phosphate (6CI, 7CI);Morphine 3-Methyl Ether Phosphate;(5a,6a)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methyl-morphinan-6-ol Phosphate
- CBNumber:
- CB8915777
- Molecular Formula:
- C18H22NO6P
- Molecular Weight:
- 379.344141
- MDL Number:
- MOL File:
- 52-28-8.mol
| Melting point | 238-240°C |
|---|---|
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | solid |
| Stability | Stable, but light sensitive. |
| FDA UNII | 2X585M1M3T |
| EPA Substance Registry System | Codeine phosphate (52-28-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334-H301-H317-H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P261-P285-P304+P341-P342+P311-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
codeine phosphate Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive. Controlled substance (opiate)
brand name
Ambenyl Cough Syrup (Parke-Davis); Colrex Compound (Solvay Pharmaceuticals).
General Description
Colorless small crystals or white powder. Odorless. Bitter taste. Solutions are acid to litmus. pH (4% solution) 4.2-5.
Air & Water Reactions
Water soluble.
Reactivity Profile
codeine phosphate is sensitive to exposure to light. . Materials that are acidic salts are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Fire Hazard
Flash point data for codeine phosphate are not available; however, codeine phosphate is probably combustible.
Contact allergens
Codeine has been reported as an occupational sensitizer in workers in the production of opium alkaloids. Codeine has been responsible for fixed drug eruptions or generalized dermatitis. Cross-sensitivity is expected to morphine.