ChemicalBook >> CAS DataBase List >>1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]-

1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]-

1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]- structure

CAS No.: 2416021-47-9

Chemical Name:: 1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]-

Synonyms: DDR1-IN-6;1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]-

CBNumber:: CB89776032

Molecular Formula:: C23H14F3N5O

Molecular Weight:: 433.39

MDL Number:

MOL File:: 2416021-47-9.mol

Last updated:2023-05-21 10:59:17

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1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]- Properties

Density	1.40±0.1 g/cm3(Predicted)
storage temp.	4°C, away from moisture and light
pka	2.95±0.30(Predicted)

1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]- Chemical Properties,Uses,Production

Description

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC₅₀ of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC₅₀ of 9.7 nM. DDR1-IN-6 has anti-cancer activity^[1].

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC₅₀=13 nM)^[1].
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC₅₀=3 μM)^[1].
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC₅₀=5.7 μM of 3 days; IC₅₀=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC₅₀>30 μM of 3 days; IC₅₀>30 μM of 6 days)^[1].

1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58

Supplier	Advantage
Aladdin Scientific	58
TargetMol Chemicals Inc.	58

1,2-Benzisoxazol-3-amine, 7-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-6-methyl-N-[3-(trifluoromethyl)phenyl]- DDR1-IN-6 2416021-47-9 C23H14F3N5O