(3S,5S)-Atorvastatin (sodium salt)
- CAS No.
- 1428118-38-0
- Chemical Name:
- (3S,5S)-Atorvastatin (sodium salt)
- Synonyms
- Atorvastatin EP Impurity E Sodium Salt;Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Sal;Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Salt
- CBNumber:
- CB93152420
- Molecular Formula:
- C33H36FN2NaO5
- Molecular Weight:
- 582.65
- MDL Number:
- MFCD18251281
- MOL File:
- 1428118-38-0.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319 |
Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
(3S,5S)-Atorvastatin (sodium salt) price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18465 | (3S,5S)-Atorvastatin (sodium salt) ≥98% | 1428118-38-0 | 1mg | $74 | 2024-03-01 | Buy |
Cayman Chemical | 18465 | (3S,5S)-Atorvastatin (sodium salt) ≥98% | 1428118-38-0 | 5mg | $330 | 2024-03-01 | Buy |
Cayman Chemical | 18465 | (3S,5S)-Atorvastatin (sodium salt) ≥98% | 1428118-38-0 | 10mg | $583 | 2024-03-01 | Buy |
TRC | A791735 | (3S,5S)-AtorvastatinSodiumSalt | 1428118-38-0 | 10mg | $590 | 2021-12-16 | Buy |
ApexBio Technology | C4030 | (3S,5S)-Atorvastatin(sodiumsalt) | 1428118-38-0 | 10mg | $666 | 2021-12-16 | Buy |
(3S,5S)-Atorvastatin (sodium salt) Chemical Properties,Uses,Production
Uses
(3S,5S)-Atorvastatin Sodium Salt (Atorvastatin EP Impurity E) is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Biological Activity
atorvastatin exists in four optical forms. the (3r, 5r)-atorvastatin enantiomer displays the greatest activity against hmg-coa reductase. (3s,5s)-atorvastatin is an enantiomer of atorvastatin with little or no inhibitory activity against hmg-coa reductase [1]. atorvastatin is a synthetic hmg-coa reductase inhibitor implicated in lowering plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. atorvastatin also reduces triglyceride levels through an as yet unproven mechanism [2]. in various trials in patients with hypercholesterolaemia, atorvastatin produced greater reductions in total cholesterol, apolipoprotein b, ldl-cholesterol and triglyceride levels. in patients with primary hypercholesterolaemia, atorvastatin in combination with colestipol produced significant reductions in ldl-cholesterol levels and smaller reductions in triglyceride levels than atorvastatin monotherapy [2].
References
[1] kocarek t a, dahn m s, cai h, et al. regulation of cyp2b6 and cyp3a expression by hydroxymethylglutaryl coenzyme a inhibitors in primary cultured human hepatocytes[j]. drug metabolism and disposition, 2002, 30(12): 1400-1405.
[2] lea a p, mctavish d. atorvastatin[j]. drugs, 1997, 53(5): 828-847.
(3S,5S)-Atorvastatin (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
(3S,5S)-Atorvastatin (sodium salt) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
Shanghai Fuyi Biological Technology Co., Ltd. | 18096642264 | sales@foreversyn.com | China | 492 | 58 |
Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1953 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10011 | 58 |
Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 40041 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |