metixene hydrochloride
- CAS No.
- 1553-34-0
- Chemical Name:
- metixene hydrochloride
- Synonyms
- SJ-1977;NSC-78194;Cholinfall;Methixene NSC 78194;Tremaril hydrochloride;Methixene hydrochloride;RSXZRFHNNTTWCB-UHFFFAOYSA-N;9-(1-Methyl-3-piperidylmethyl)thioxanthene hydrochloride;1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine hydrochloride;1-Methyl-3-(9H-thioxanthen-9-ylMethyl)-piperidine hydrochloride (1:1)
- CBNumber:
- CB9926037
- Molecular Formula:
- C20H23NS.ClH
- Molecular Weight:
- 345.936
- MDL Number:
- MFCD01700364
- MOL File:
- 1553-34-0.mol
| Melting point | 209-210 °C |
|---|---|
| FDA UNII | FRK5BSL54S |
metixene hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M338970 | Metixene hydrochloride | 1553-34-0 | 10mg | $195 | 2021-12-16 | Buy |
| TRC | M338970 | Metixene hydrochloride | 1553-34-0 | 100mg | $1540 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 60390 | MetixeneHCl | 1553-34-0 | 100mg | $2400 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 60390 | MetixeneHCl | 1553-34-0 | 10mg | $675 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0077143 | METIXENE HYDROCHLORIDE 95.00% | 1553-34-0 | 5G | $909.56 | 2021-12-16 | Buy |
metixene hydrochloride Chemical Properties,Uses,Production
Originator
Tremarit Wander W. Germany,Wander ,W. Germany,1960
Uses
Metixene Hydrochloride is used for the suppression of Parkinsonian tremor and has therapeutic properties.
Manufacturing Process
To 4.9 g of finely pulverized sodium in 50 ml of absolute benzene add dropwise with stirring 12 g of chlorobenzene in 50 ml of absolute benzene. As soon as the exothermic reaction begins, maintain the temperature by cooling between 30° and 35°C, and continue stirring for 2 to 3 hours. To the resulting phenyl sodium add dropwise 19.8 g of thioxanthene in 120 ml of absolute benzene. The slightly exothermic reaction ceases after about 1 to 1? hours.
To this newly formed 9-thioxanthyl sodium add dropwise, with stirring and cooling, 13.1 g of N-methyl-3-chloromethyl-piperidine in 30 to 40 ml of absolute benzene, then continue stirring at about 25°C for 1? hours, and heat subsequently to 40°C for 1 hour. Decompose the resulting mixture by adding carefully a small amount of water, and then extract the newly formed base from the benzene solution by means of dilute hydrochloric acid. The aqueous hydrochloric solution is made alkaline by adding dilute sodium hydroxide, and the thioxanthene base is isolated by extraction with ether. This results in 22 g of a slightly yellow, viscous base of BP 171° to 175°C/0.07 mm.
The base is acidified with alcoholic hydrochloric acid. Alcohol-ether (1:2) is then added and the hydrochloride salt is crystallized as colorless flakes melting at 211° to 213°C.
Therapeutic Function
Spasmolytic
metixene hydrochloride Preparation Products And Raw materials
metixene hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9906 | 55 |
| Megchem Co., Ltd. | +86 (21) 5471-7132 | China | 345 | 58 | |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9946 | 58 |