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ChemicalBook >> CAS DataBase List >>Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]-

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]-

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- Structure
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- structure
CAS No.
2055741-39-2
Chemical Name:
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]-
Synonyms
IV-361;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]-
CBNumber:
CB99769330
Molecular Formula:
C23H32FN5O2Si
Molecular Weight:
457.62
MDL Number:
MOL File:
2055741-39-2.mol
Last updated:2023-05-21 10:59:17
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Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- Properties

Boiling point 660.7±55.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 90 mg/mL (196.67 mM; Need ultrasonic)
pka 11.47±0.70(Predicted)

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- Chemical Properties,Uses,Production

Biological Activity

IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1]. IV-361 has less inhibition on CDK2 (Ki≥1000 nM) or PLK1 (Ki≥5000 nM)[1]. IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC50≤100 nM) in periphery blood mononuclear cell (PBMC)[1]. IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI50≤100 nM)[1]. IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1].

References

[1]. Noriaki Iwase, et al. Substituted dihydropyrrolopyrazole derivative. US20190256531A1.

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
Aladdin Scientific 		58
TargetMol Chemicals Inc. 58
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(5-fluoro-2-methylphenyl)-4,6-dihydro-6,6-dimethyl-3-[[[1-(trimethylsilyl)cyclobutyl]carbonyl]amino]- IV-361 2055741-39-2 C23H32FN5O2Si