1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン
1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン 物理性質
- 融点 :
- ~130 °C (dec.)
- 比旋光度 :
- 12.5 º (C=1% IN MEOH)
- 沸点 :
- 667.5±55.0 °C(Predicted)
- 比重(密度) :
- 1.16±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Keep in dark place,Sealed in dry,Room Temperature
- 溶解性:
- DMSO（少々）、メタノール（少々）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 3.17±0.10(Predicted)
- 色:
- ホワイトからオフホワイト
- 光学活性 (optical activity):
- [α]20/D +12.5±1.0°, c = 1% in methanol
- BRN :
- 732035
- InChIKey:
- OYXZPXVCRAAKCM-SANMLTNESA-N
- SMILES:
- C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
- CAS データベース:
- 32926-43-5(CAS DataBase Reference)
1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン 価格
もっと(13)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBSS-8974 |
(S)-L-Boc-His(Trt)-OH |
32926-43-5 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBSS-8974 |
(S)-L-Boc-His(Trt)-OH |
32926-43-5 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
15449 |
≥98.0% (TLC)
Boc-His(Trt)-OH ≥98.0% (TLC) |
32926-43-5 |
1g |
￥5440 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS093555 |
Boc-His(Trt)-OH |
32926-43-5 |
1g |
￥43700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS093555 |
Boc-His(Trt)-OH |
32926-43-5 |
5g |
￥115900 |
2024-03-01 |
購入 |
1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン 化学特性,用途語,生産方法
化学的特性
White to off white powder
使用
Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.
使用
Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.
主な応用
N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.
製造方法
The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et
2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.
reaction suitability
Reaction type: Boc solid-phase peptide synthesis
1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン 上流と下流の製品情報
原材料
準備製品
1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン 生産企業
Global( 229)Suppliers
32926-43-5(1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン)キーワード:
- 32926-43-5
- (S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid
- N-Boc-His(Trt)-OH
- (S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95%
- Boc-His(Trt)-OH >=98.0% (TLC)
- Boc-His(Trt)-OH, >=98%
- (S)-L-Boc-his(trt)-oh
- BOC-N-IM-TRITYL-L-HISTIDINE
- N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE
- N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE
- N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE
- N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE
- N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE
- L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-
- Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity)
- N-Boc-N'-trityl-L-histidine
- (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
- Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine
- (Tert-Butoxy)Carbonyl His(Trt)-OH
- 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID
- N-Boc-N'-trityl-L-histidine USP/EP/BP
- Nα-Boc-Nim-trityl-L-histidine
- N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine
- (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid
- His(Trt)-OH
- BOC-L-HIS(TRT)-OH
- BOC-HIS(TRT)-OH
- Boc-His(trt)
- Boc-L-His(Trt)
- Nα-Boc-N(im)-trityl-L-histidine
- N-Boc N '- Triphenylmethyl L-histidine
- (2S)-2-{[(tert-ブトキシ)カルボニル]アミノ}-3-[1-(トリフェニルメチル)-1H-イミダゾール-4-イル]プロパン酸
- 1-トリチル-Nα-(tert-ブチルオキシカルボニル)-L-ヒスチジン