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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride

化学構造式
177943-33-8
CAS番号.
177943-33-8
化学名:
别名:
英語名:
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
英語别名:
PF-04859989HCl;PF-04859989 HCl;PF04859989 hydrochloride;PF-4859989 hydrochloride;PF-04859989 hydrochloride;PF-04859989 hydrochloride >=98% (HPLC);(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
CBNumber:
CB42598844
化学式:
C9H11ClN2O2
分子量:
214.64884
MOL File:
177943-33-8.mol

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 物理性質

貯蔵温度 :
room temp
溶解性:
H2O: 可溶20mg/mL、透明
外見 :
粉
色:
白からベージュ
水溶解度 :
Water: 22 mg/ml

安全性情報

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan PZ0250 ≥98% (HPLC)
PF-04859989 hydrochloride ≥98% (HPLC)		 177943-33-8 5mg ￥19900 2024-03-01 購入
Sigma-Aldrich Japan PZ0250 ≥98% (HPLC)
PF-04859989 hydrochloride ≥98% (HPLC)		 177943-33-8 25mg ￥80100 2024-03-01 購入

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 化学特性,用途語,生産方法

Biochem/physiol Actions

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 上流と下流の製品情報

原材料

準備製品

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 生産企業

Global( 20)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861
 contact@labnetwork.com China 19994 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 18521735133 18521732826;
 market@aladdin-e.com China 25014 65
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
ShangHai Angti Biotechnology Co., Ltd. 13764913901
 info@angtibio.com China 4722 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9709 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088
 3193328036@qq.com China 29796 68
Tianjin heowns Biochemical Technology Co., Ltd. 400-6387771-6039 18920564737
 sales@heowns.com China 20555 60
Jiangsu aikang biomedical research and development co., LTD 025-66110311 13155353615
 qzhang@aikonchem.com China 15527 58

  スペクトルデータ(1HNMR)

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride(177943-33-8)1HNMR
  • 177943-33-8
  • (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
  • (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
  • L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
  • PF04859989 hydrochloride
  • PF-04859989 hydrochloride
  • PF-4859989 hydrochloride
  • PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
  • PF-04859989 hydrochloride >=98% (HPLC)
  • 2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
  • (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
  • PF-04859989 HCl
  • PF-04859989HCl
  • disorders,schizophrenia,Inhibitor,inhibit,PF04859989 HCl,midbrain,psychiatric,PF 04859989 HCl,dopamine,neurons,cognitive ,impairment
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