ダントロレンナトリウム七水和物 化学特性,用途語,生産方法
外観
橙色～橙褐色, 結晶または塊
効能
骨格筋弛緩薬
商品名
ダントリウム (オーファンパシフィック); ダントリウム (オーファンパシフィック)
化学的特性
Orange Powder
使用
Dantrolene Sodium Salt Hemiheptahydrate is a muscle relaxant (skeletal). Used in the treatment of malignant hyperthermia.
定義
ChEBI: A hydrate which is the hemiheptahydrate of anhydrous dantrolene sodium.
生物学の機能
Dantrolene sodium (Dantrium) is used in the treatment
of spasticity due to stroke, spinal injury, multiple sclerosis,
or cerebral palsy. It is also the drug of choice in prophylaxis
or treatment of malignant hyperthermia.
Susceptibility to malignant hyperthermia is due to a
rare genetic defect that allows Ca
++ release from the
sarcoplasmic reticulum to open more easily and close
less readily than normal. This leads to a high level of
Ca
++ in the sarcoplasm, which produces muscle rigidity,
oxygen consumption, and heat. Dantrolene acts by
blocking Ca
++ release from the sarcoplasmic reticulum
and uncoupling excitation from contraction.
Dantrolene is active orally, although its absorption is
slow and incomplete. Its biological half-life (t
1/2) is 8.7
hours in adults. The drug is metabolized by liver microsomal
enzymes and is eliminated in the urine and bile.
It is given IV when treating an attack of malignant hyperthermia.
The most prominent and often limiting feature of
dantrolene administration is dose-dependent muscle
weakness. Other side effects are drowsiness, dizziness,
malaise, fatigue, and diarrhea. Symptomatic hepatitis is
reported in 0.5% of patients receiving it and fatal hepatitis
in up to 0.2%. Contraindications include respiratory
muscle weakness and liver disease. It is suggested
that patients on dantrolene therapy be given regular
liver function tests.
ダントロレンナトリウム七水和物 上流と下流の製品情報
原材料
準備製品