カルトゲニン
カルトゲニン 物理性質
- 融点 :
- 272 °C
- 沸点 :
- 464.4±38.0 °C(Predicted)
- 比重(密度) :
- 1.289±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- room temp
- 溶解性:
- DMSO：>15mg/mL
- 外見 :
- 粉
- 酸解離定数(Pka):
- 3.45±0.36(Predicted)
- 色:
- 白い
- 安定性：:
- -20°C の DMSO またはエタノール溶液で最大 3 か月間保存できます。
- InChIKey:
- SLUINPGXGFUMLL-UHFFFAOYSA-N
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQI-2283 |
カルトゲニン
Kartogenin |
4727-31-5 |
250mg |
￥30000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQI-2283 |
カルトゲニン
Kartogenin |
4727-31-5 |
1g |
￥75000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQI-2283 |
Kartogenin |
4727-31-5 |
25g |
￥640000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0370 |
カルトゲニン ≥98% (HPLC)
Kartogenin ≥98% (HPLC) |
4727-31-5 |
5mg |
￥19900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0370 |
カルトゲニン ≥98% (HPLC)
Kartogenin ≥98% (HPLC) |
4727-31-5 |
25mg |
￥58800 |
2024-03-01 |
購入 |
カルトゲニン 化学特性,用途語,生産方法
説明
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC
50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-
binding protein, filamin A, which disrupts its interaction with the transcription factor core-
binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-
related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-
induced damage in osteoarthritic bovine articular chondrocytes
in vitro.
使用
Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.
Biochem/physiol Actions
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
カルトゲニン 上流と下流の製品情報
原材料
準備製品
カルトゲニン 生産企業
Global( 144)Suppliers
カルトゲニン スペクトルデータ(1HNMR、MS)
4727-31-5(カルトゲニン)キーワード:
- 4727-31-5
- 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid
- 2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
- Kartogenin(KGN)
- 4'-Phenylphthalanilic Acid
- Kartogenin
- KGN
- 2-([1,1'-biphenyl]-4-ylcarbaMoyl)benzoic acid
- 4′-Phenyl-phthalanilic acid (8CI)
- n-Biphenyl-4-yl-phthalamic acid
- 100822
- CS-612
- 2-[(4-phenylphenyl)carbamoyl]benzoic Acid
- Benzoic acid, 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-
- KGN USP/EP/BP
- 2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid
- カルトゲニン