(16S)-20-エチル-1α,6α,16-トリメトキシ-4-メトキシメチルアコニタン-3α,8,13,14α-テトラオール8-アセタート14-(3,4-ジメトキシベンゾアート) 化学特性,用途語,生産方法
説明
An aconitine alkaloid obtained from A coniturn chasrnanthurn Stapf. by Dunstan
and Andrews, the base crystallizes from EtOH as hexagonal prisms or rosettes of
fine needles. It has [α]
20Do + IS.3° (EtOH) and gives a series of crystalline salts,
e.g. the hydrobromide as hexagonal prisms from H20, m.p. lS3-7°C; [edo -
17.3° or as crystals from EtOH or Et 20, m.p. 217 -SoC and the aurichloride,
yellow needles, m.p. 147 -152°C with sintering at 142°C. Indaconitine resembles
Aconitine (q. v.) in giving a crystalline precipitate with KMn04 but in this case
the crystals are markedly smaller. Four methoxyl groups are present and when
the SUlphate is heated in aqueous solution in a sealed tube it furnishes acetic acid
and benzoylpseudaconine (Indbenzaconine), as a colourless glass, m.p. 130-3°C;
[α]
D + 33.6° (EtOH), also giving crystalline salts: hydrochloride, m.p. 242-4°C;
[α]
D - S.Oo (H 20); hydrobromide as the dihydrate, m.p. 247°C (dry) and the
aurichloride, rosettes of orange needles, m.p. 180-2°C.
Alkaline hydrolysis gives acetic and benzoic acids and pseudaconine,
C2sH4108N. On pyrolysis, the alkaloid loses one mole of acetic acid with the
formation of a-pyroindaconitine which is amorphous, m.p. 130-2°C; [α]
D +
91.9° (EtOH), giving a crystalline hydro bromide, m.p. 194-SoC. When inda_x0002_conitine hydrochloride is subjected to the same treatment it yields the isomeric
~-pyroindaconitine, also amorphous, but furnishing a crystalline hydrobromide,
m.p. 24S-250°C; [α]
D + 27.6°.
化学的特性
White crystalline, amorphous, or syrupy sub stance; salts are optically active; melts at214°C (417.2°F); insoluble in water, solublein alcohol, ether, and chloroform.
使用
8-Acetyl ludaconitine occurs in the tubers of Indianaconite (bish or Aconitum ferox), found inIndia and Nepal. It is used in arrow poisoningfor hunting. Clinically, it is used in treatingrheumatism.
健康ハザード
Feraconitine is a highly toxic alkaloid. Theacute toxic effects are similar to those ofaconitine. The symptoms from ingestionare drowsiness, nervous disorders, weakness,.
参考文献
Dunstan, Andrews, J. Chern. Soc., 87, 1620 (1905)
See also:
Bauer, Radjhan., Pharrn. Zent., 72,145 (1931)
(16S)-20-エチル-1α,6α,16-トリメトキシ-4-メトキシメチルアコニタン-3α,8,13,14α-テトラオール8-アセタート14-(3,4-ジメトキシベンゾアート) 上流と下流の製品情報
原材料
準備製品