Chlormadinone acetate manufacturers and suppliers

Chlormadinone acetate suppliers

Properties

Melting point:: 212°C

alpha: D +6° (c = 1 in CHCl3)

Boiling point:: 512.5±50.0 °C(Predicted)

Density: 1.1345 (estimate)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

color: Off-White to Light Yellow

λmax: 285nm(EtOH)(lit.)

Merck: 14,2102

BRN: 2633614

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H351-H360

Precautionary statements: P202-P405-P501-P201-P280-P308+P313-P281

Hazard Codes: T

Risk Statements: 60-61-40-48

Safety Statements: 53-22-36/37/39-45

WGK Germany: 3

RTECS: TU3750000

HS Code: 29372390

Toxicity: mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977.

Use

Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)

You can find Chlormadinone acetate suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.