Sulindac manufacturers and suppliers

Sulindac suppliers

Properties

Melting point:: 182-185°C

Boiling point:: 581.6±50.0 °C(Predicted)

Density: 1.2581 (estimate)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Very slightly soluble in water, soluble in methylene chloride, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.

pka: pKa (25°) 4.7

color: Light yellow to Brown

Water Solubility: Soluble in water, methanol, ethanol.

λmax: 327nm(0.05mol/L methanolic HCl)(lit.)

Merck: 14,8982

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H317-H334-H361

Precautionary statements: P261-P280-P284-P301+P330+P331+P310-P304+P340-P342+P311

Hazard Codes: Xn

Risk Statements: 22-63-42/43

Safety Statements: -

RIDADR: 3249

WGK Germany: 3

RTECS: NK8226000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29309090

Use

Sulindac, (Z)-5-fluoro-2-methyl-1-([p-(methylsulfinyl)phenyl]methylene)-1H-indene-3-acetic acid (Clinoril), isan NSAID prodrug that contains a chiral sulfoxide moietybut is marketed as the racemate because it undergoes invivo reduction by the hepatic enzymes into its achiral, activemetabolite, methyl sulfide that exhibits potent andnonselective COX inhibition similar to indomethacin.The parent sulfoxide has a plasma half-life of 8 hours, andthe active methyl sulfide metabolite is 16.4 hours. The morepolar and inactive sulfoxide is virtually the only form excretedinto the renal tubules, thus sulindac is believed to haveminimal nephrotoxicity associated with indomethacin. Thelong half-life of sulindac is caused by the extensive enterohepaticcirculation and reactivation of the inactive sulfoxideexcreted. Coadministration of aspirin is contraindicated becauseit considerably reduces the sulfide blood levels. Carefulmonitoring of patients with a history of ulcers is recommended.Gastric bleeding, nausea, diarrhea, dizziness, andother adverse effects have been noted with sulindac, but witha lower frequency than with aspirin. Sulindac is recommendedfor RA, OA, and ankylosing spondylitis.

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