COUMERMYCIN A1
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- $158 - $1000
- Product name: COUMERMYCIN A1
- CAS: 4434-05-3
- MF: C55H59N5O20
- MW: 1110.08
- EINECS:
- MDL Number:MFCD00864860
- Synonyms:coumamycin ;coumermycins ;iyl)bis(carbonylimino))bis(7-((5,5-di-c-methyl-4-o-methyl-alpha-l-lyxopyranosy ;l)oxy)-4-hydroxy-8-methylcoumarin) ;notomycina1 ;pyrrole-2-carboxylicacid,5-methyl-,diesterwith3,3’-((3-methylpyrrole-2,4-d ;Coumermycin;Cumamycin
3 prices
Selected condition：
Brand
- Sigma-Aldrich
Package
- 5mg
- 10mg
- 50mg
- ManufacturerSigma-Aldrich
- Product numberC9270
- Product descriptionCoumermycin A1
- Packaging5mg
- Price$158
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberC9270
- Product descriptionCoumermycin A1
- Packaging10mg
- Price$252
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberC9270
- Product descriptionCoumermycin A1
- Packaging50mg
- Price$1000
- Updated2023-06-20
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | C9270 | Coumermycin A1 | 5mg | $158 | 2023-06-20 | Buy |
| Sigma-Aldrich | C9270 | Coumermycin A1 | 10mg | $252 | 2023-06-20 | Buy |
| Sigma-Aldrich | C9270 | Coumermycin A1 | 50mg | $1000 | 2023-06-20 | Buy |
Properties
Melting point :259°C (rough estimate)
Boiling point :821.5°C (rough estimate)
Density :1.1866 (rough estimate)
refractive index :1.7210 (estimate)
storage temp. :Store at -20°C
solubility :DMSO: 50 mg/mL, clear, faintly yellow
pka :pKa 6.0±0.02(H2O ) (Uncertain)
form :powder
BRN :470805
Boiling point :821.5°C (rough estimate)
Density :1.1866 (rough estimate)
refractive index :1.7210 (estimate)
storage temp. :Store at -20°C
solubility :DMSO: 50 mg/mL, clear, faintly yellow
pka :pKa 6.0±0.02(H2O ) (Uncertain)
form :powder
BRN :470805
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Coumermycin A1, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A1 can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.More related product prices
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Suppliers and manufacturers
BOC Sciences
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
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Wuhan Jingkang en Biomedical Technology Co., Ltd
Nantong QuanYi Biotechnology Co., Ltd
BOC Sciences
Guangzhou Isun Pharmaceutical Co., Ltd
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Rechem science Co., Ltd.