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ChemicalBook >> CAS DataBase List >> KU-55933

KU-55933

KU-55933 price.
  • $28 - $3176.25
  • Product name: KU-55933
  • CAS: 587871-26-9
  • MF: C21H17NO3S2
  • MW: 395.49
  • EINECS:
  • MDL Number:MFCD08276985
  • Synonyms:2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE;2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one;KU-55933 (ATM Kinase Inhibitor);KU-55933, >99%;KV-55933;2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one;2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor);KU 55933, >=98%
36 prices
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  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1MG
  • 10mM(in 1mL DMSO)
  • 1unit
  • 5mg
  • 10mg
  • 2x10mg
  • 25MG
  • 50mg
  • 100mg
  • 200mg
  • 250MG
  • 500MG
  • 1G
  • 25 mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1051-M005
  • Product descriptionKU-55933 ≥95%
  • Packaging5mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7425
  • Product descriptionKU-55933
  • Packaging10mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7425
  • Product descriptionKU-55933
  • Packaging100mg
  • Price$468
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000146
  • Product descriptionKU-55933 95.00%
  • Packaging1MG
  • Price$166.95
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000146
  • Product descriptionKU-55933 95.00%
  • Packaging250MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000146
  • Product descriptionKU-55933 95.00%
  • Packaging500MG
  • Price$2310
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000146
  • Product descriptionKU-55933 95.00%
  • Packaging1G
  • Price$3176.25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4605
  • Product descriptionKU55933
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4605
  • Product descriptionKU55933
  • Packaging10mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4605
  • Product descriptionKU55933
  • Packaging10mM(in 1mL DMSO)
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4605
  • Product descriptionKU55933
  • Packaging50mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4605
  • Product descriptionKU55933
  • Packaging100mg
  • Price$352
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1367
  • Product descriptionKU55933 99%
  • Packaging10mg
  • Price$137.5
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1367
  • Product descriptionKU55933 99%
  • Packaging2x10mg
  • Price$198
  • Updated2021-12-16
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  • ManufacturerAxon Medchem
  • Product numberAxon1367
  • Product descriptionKU55933 99%
  • Packaging50mg
  • Price$412.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBK43330
  • Product descriptionKU 55933 NEW
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1051-M005 KU-55933 ≥95% 5mg $76 2021-12-16 Buy
AK Scientific X7425 KU-55933 10mg $84 2021-12-16 Buy
AK Scientific X7425 KU-55933 100mg $468 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000146 KU-55933 95.00% 1MG $166.95 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000146 KU-55933 95.00% 250MG $1732.5 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000146 KU-55933 95.00% 500MG $2310 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000146 KU-55933 95.00% 1G $3176.25 2021-12-16 Buy
ApexBio Technology A4605 KU55933 1unit $28 2021-12-16 Buy
ApexBio Technology A4605 KU55933 10mg $62 2021-12-16 Buy
ApexBio Technology A4605 KU55933 10mM(in 1mL DMSO) $70 2021-12-16 Buy
ApexBio Technology A4605 KU55933 50mg $198 2021-12-16 Buy
ApexBio Technology A4605 KU55933 100mg $352 2021-12-16 Buy
Axon Medchem Axon1367 KU55933 99% 10mg $137.5 2021-12-16 Buy
Axon Medchem Axon1367 KU55933 99% 2x10mg $198 2021-12-16 Buy
Axon Medchem Axon1367 KU55933 99% 50mg $412.5 2021-12-16 Buy
Biosynth Carbosynth BK43330 KU 55933 NEW 10mg $85 2021-12-16 Buy

Properties

Boiling point :628.0±55.0 °C(Predicted)
Density :1.419±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
pka :0.33±0.20(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM; Ki = 2.2 nM). Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents. Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death. It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 μM.

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