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ChemicalBook >> CAS DataBase List >> ML 141

ML 141

ML 141 price.
  • $32 - $2193
  • Product name: ML 141
  • CAS: 71203-35-5
  • MF: C22H21N3O3S
  • MW: 407.49
  • EINECS:
  • MDL Number:MFCD05987165
  • Synonyms:4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide;CID-2950007;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide;ML 141;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem;4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE TRIHYDROCHLORIDE
Price34 Properties Safety Information Description
34 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 2mg
  • 1MG
  • 50
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2551AH
  • Product description4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
  • Packaging2mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA201975
  • Product description4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+%
  • Packaging5mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA201975
  • Product description4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+%
  • Packaging10mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA201975
  • Product description4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+%
  • Packaging50mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA201975
  • Product description4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+%
  • Packaging1g
  • Price$2193
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010286
  • Product description4-[4,5-DIHYDRO-5-(4-METHOXYPHENYL)-3-PHENYL-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 95.00%
  • Packaging1MG
  • Price$135.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010286
  • Product description4-[4,5-DIHYDRO-5-(4-METHOXYPHENYL)-3-PHENYL-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 95.00%
  • Packaging10MG
  • Price$782.23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010286
  • Product description4-[4,5-DIHYDRO-5-(4-METHOXYPHENYL)-3-PHENYL-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 95.00%
  • Packaging50MG
  • Price$1376.48
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB9014
  • Product descriptionML 141
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18496
  • Product descriptionML 141 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18496
  • Product descriptionML 141 ≥98%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18496
  • Product descriptionML 141 ≥98%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM189197
  • Product description4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98%
  • Packaging100mg
  • Price$646
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3940
  • Product descriptionML 141 99.71%
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3940
  • Product descriptionML 141 99.71%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3940
  • Product descriptionML 141 99.71%
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2551AH 4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide 2mg $113 2021-12-16 Buy
Ambeed A201975 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+% 5mg $58 2021-12-16 Buy
Ambeed A201975 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+% 10mg $76 2021-12-16 Buy
Ambeed A201975 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+% 50mg $129 2021-12-16 Buy
Ambeed A201975 4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98+% 1g $2193 2021-12-16 Buy
American Custom Chemicals Corporation API0010286 4-[4,5-DIHYDRO-5-(4-METHOXYPHENYL)-3-PHENYL-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 95.00% 1MG $135.45 2021-12-16 Buy
American Custom Chemicals Corporation API0010286 4-[4,5-DIHYDRO-5-(4-METHOXYPHENYL)-3-PHENYL-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 95.00% 10MG $782.23 2021-12-16 Buy
American Custom Chemicals Corporation API0010286 4-[4,5-DIHYDRO-5-(4-METHOXYPHENYL)-3-PHENYL-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 95.00% 50MG $1376.48 2021-12-16 Buy
ApexBio Technology B9014 ML 141 5mg $110 2021-12-16 Buy
Cayman Chemical 18496 ML 141 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 18496 ML 141 ≥98% 5mg $100 2024-03-01 Buy
Cayman Chemical 18496 ML 141 ≥98% 10mg $184 2024-03-01 Buy
Chemenu CM189197 4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide 98% 100mg $646 2021-12-16 Buy
ChemScene CS-3940 ML 141 99.71% 5mg $84 2021-12-16 Buy
ChemScene CS-3940 ML 141 99.71% 10mg $150 2021-12-16 Buy
ChemScene CS-3940 ML 141 99.71% 50mg $540 2021-12-16 Buy
Next Last

Properties

Melting point :216 °C(Solv: ethanol (64-17-5))
Boiling point :622.9±65.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (warmed, clear solution)
form :Yellow-white solid
pka :10.39±0.10(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML 141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 μM) with no inhibitory action against Rho, Ras, Rab, or Rac. It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 μM). ML 141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin. It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity.

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