ML115
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- $49 - $2237
- Product name: ML115
- CAS: 912798-42-6
- MF: C15H15ClN2O4
- MW: 322.7436
- EINECS:
- MDL Number:MFCD09782805
- Synonyms:ML115;ML115,ML-115;3-Isoxazolecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-
7 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 100mg
- ManufacturerAK Scientific
- Product numberSYN5305
- Product descriptionML115
- Packaging10mg
- Price$362
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5305
- Product descriptionML115
- Packaging100mg
- Price$2237
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15178
- Product descriptionML115 ≥98%
- Packaging500μg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15178
- Product descriptionML115 ≥98%
- Packaging1mg
- Price$92
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15178
- Product descriptionML115 ≥98%
- Packaging5mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberM425170
- Product descriptionML115
- Packaging25mg
- Price$1075
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number456366
- Product descriptionML115
- Packaging500μg
- Price$312
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5305 | ML115 | 10mg | $362 | 2021-12-16 | Buy |
| AK Scientific | SYN5305 | ML115 | 100mg | $2237 | 2021-12-16 | Buy |
| Cayman Chemical | 15178 | ML115 ≥98% | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 15178 | ML115 ≥98% | 1mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 15178 | ML115 ≥98% | 5mg | $356 | 2024-03-01 | Buy |
| TRC | M425170 | ML115 | 25mg | $1075 | 2021-12-16 | Buy |
| Usbiological | 456366 | ML115 | 500μg | $312 | 2021-12-16 | Buy |
Properties
Boiling point :422.9±45.0 °C(Predicted)
Density :1.389±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 16 mg/ml; Ethanol: 0.1 mg/ml
form :A crystalline solid
pka :9.26±0.70(Predicted)
Density :1.389±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 16 mg/ml; Ethanol: 0.1 mg/ml
form :A crystalline solid
pka :9.26±0.70(Predicted)
Safety Information
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| Signal word: | Warning | |||||||
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Description
Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.More related product prices
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