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ChemicalBook >> CAS DataBase List >> NO-LOSARTAN A

NO-LOSARTAN A

NO-LOSARTAN A price.
  • $19 - $595
  • Product name: NO-LOSARTAN A
  • CAS: 791122-48-0
  • MF: C30H28ClN7O5
  • MW: 602.04
  • EINECS:
  • MDL Number:MFCD08062179
  • Synonyms:[2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOL-5-YL] METHYL ESTER 3-[(NITROOXY)METHYL]-BENZOIC ACID;NO-LOSARTAN A;MWJCPZGVGOVWQZ-UHFFFAOYSA-N;NOLosartan A,NO Losartan A;Benzoic acid, 3-[(nitrooxy)methyl]-, [2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl]methyl ester
Price5 Properties Safety Information Description
5 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • ManufacturerAK Scientific
  • Product number1947AH
  • Product descriptionNO-LosartanA
  • Packaging5mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006456
  • Product descriptionNO-Losartan A ≥97%
  • Packaging1mg
  • Price$19
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006456
  • Product descriptionNO-Losartan A ≥97%
  • Packaging5mg
  • Price$78
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006456
  • Product descriptionNO-Losartan A ≥97%
  • Packaging10mg
  • Price$138
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006456
  • Product descriptionNO-Losartan A ≥97%
  • Packaging50mg
  • Price$595
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1947AH NO-LosartanA 5mg $185 2021-12-16 Buy
Cayman Chemical 10006456 NO-Losartan A ≥97% 1mg $19 2024-03-01 Buy
Cayman Chemical 10006456 NO-Losartan A ≥97% 5mg $78 2024-03-01 Buy
Cayman Chemical 10006456 NO-Losartan A ≥97% 10mg $138 2024-03-01 Buy
Cayman Chemical 10006456 NO-Losartan A ≥97% 50mg $595 2024-03-01 Buy

Properties

Boiling point :818.4±75.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:5): .5 mg/ml
form :A crystalline solid
pka :4.16±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.3 In humans, losartan effectively controls hypertension while protecting renal function.4 Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.5,6 NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.7

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Suppliers and manufacturers

Shanghai Hongye Biotechnology Co. Ltd MedBioPharmaceutical Technology Inc TargetMol Chemicals Inc. Shanghai Yifei Biotechnology Co. , Ltd.