| | 745833-23-2 Basic information More.. |
| Product Name: | VX 702 | | Synonyms: | 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;VX 702;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702;VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;VX702;VX-702;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide;(479543-46-9) vx 702;CS-1840 | | CAS: | 745833-23-2 | | MF: | C19H12F4N4O2 | | MW: | 404.32 | | EINECS: | | | Mol File: | 745833-23-2.mol |  |
Use
VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]
- VX 702
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- US $100.00 / KG
- 2023-08-16
- CAS:745833-23-2
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 50000kg/Month
- VX 702
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- US $7.00 / KG
- 2019-07-06
- CAS: 745833-23-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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745833-23-2
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